--- Log opened Fri Nov 24 00:00:24 2017
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05:52 < ebowden> https://www.youtube.com/watch?v=0QrynzJ_lZ4
05:59 < kanzure> .title
05:59 < yoleaux> How carbide inserts are made by Sandvik Coromant - YouTube
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06:46 < kanzure> baseline test https://www.youtube.com/watch?v=l7BDuTiHC3I
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06:57 < kanzure> ( https://www.youtube.com/watch?v=3Q-FJ203nJo )
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10:22 < kanzure> blort
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11:33 < nmz787> so transient expression of plasmids in tissues is a problem, first obvious issue is transformation efficiency, which might be helped by electroporation somehow... but I'm not sure just how
11:34 < nmz787> maybe something like a microneedle array, where each needle can also act as an electrode
11:43 < kanzure> put the plasmids into bacteria, put the bacteria in the tissue, problem solved?
11:47 < streety> could also ask whether transient expression of a plasmid is the best approach to the task
11:52 < kanzure> oumuamua interception mission https://arxiv.org/abs/1711.03155
11:52 < kanzure> "To maximize science return decelerating the spacecraft at 'Oumuamua is highly desirable, due to the minimal science return from a hyper-velocity encounter."
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11:55 < nmz787> kanzure: haha, good joke
11:56 < nmz787> streety: I don't want non-transient expression
11:58 < nmz787> I'm also thinking a modified tattoo gun could work, as the needle travels down into the tissue it could emit plasmid solution, the needle could also act as an electrode (the tip would only be conductive, the shaft being insulated)... as the needle travels down the voltage would increase on the pulses from the tip, so the field strength (volts per cm) would remain constant/similar-enough
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13:11 < streety> what effect are you looking for? If expression of some biological perhaps recombinant production of the biological and then injection would be an alternative
13:14 < nmz787> the prolactin hormone gene, to produce prolactin hormone, to achieve lactation in a single breast
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13:17 < streety> injection of recombinant protein is an option then
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15:23 < kanzure> are there parts of the human population that undergo spontaneous age reversal? if we just monitor everyone maybe we can find someone that periodically has ~2 month cleanup as spontaneous events that can be studied.
15:23 < kanzure> by age reversal i mean minor age reversal (months or a year at most)
15:23 < kanzure> certainly seems like aging gets stuck for long stretches of time until sufficiently stressed (or whatever)
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15:28 < kanzure> i think we can stall aging but i wouldn't count on fixing it
15:28 < kanzure> also there's lots of longevity alleles, and even extended prepubescence alleles
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16:11 < kanzure> "When taking antibiotics, people report having wild, vivid dreams. ... Clindamycin, doxycycline, and quinolone antibiotics"
16:13 < rpifan> kanzure, i agree with that
16:13 < rpifan> on both statements
16:13 < rpifan> i know for a fact ppl who lose age
16:13 < rpifan> or who look a lot younger then they should
16:13 < rpifan> and also when i was one bactrim for pnuemonia 3 times a day
16:13 < rpifan> it kept me up more then adderal
16:15 < gradstudentbot> I don't know whether I am Turing dreaming that I am a machine, or a machine dreaming that I am Turing!
16:15 < rpifan> oh
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16:30 < kanzure> "That’s what Dani Clode’s Third Thumb project... The thumb, 3D printed from a variant of Thermoplastic Polyurethane (TPU) called Ninjaflex, sits right beside your little finger. It’s connected to a smart-bracelet that receives its commands via bluetooth from the wearer’s foot. Pressure sensors are placed on the soles of the feet and any force you apply with your foot is perceived as a ...
16:30 < kanzure> ...signal by the bracelet i.e., if you press down with one foot, the thumb flexes inwards, grasping whatever you’re holding."
16:31 < kanzure> "in this case, an extra thumb. With the aim of adding to human’s possibilities, rather than replacing what’s lost"
16:31 < kanzure> .title https://vimeo.com/220291411
16:32 < yoleaux> The Third Thumb Project on Vimeo
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17:19 < kanzure> https://www.fietsenwinkel.nl/fietsen/-/elektrische_fietsen/speed_pedelecs/
17:20 < kanzure> https://www.brompton.com/Brompton-Electric
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17:34 < kanzure> why doesn't lab equipment travel with the scientist
17:35 < kanzure> who came up with the "leave it at school" model?
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18:00 < kanzure> https://www.newscientist.com/article/mg23631520-100-biohackers-are-using-crispr-on-their-dna-and-we-cant-stop-it/
18:00 < kanzure> full text available here http://postbiota.org/pipermail/tt/2017-November/020889.html
18:10 < ebowden> I wonder how much of a drop in cancer rates you could get with a bunch of extra copies of P53.
18:10 < kanzure> it's listed multiple times on http://diyhpl.us/wiki/genetic-modifications/
18:22 < ebowden> I wonder if there are any APP mutations that reduce Alzheimer's risk.
18:26 < kanzure> do you just not read my links? :(
18:26 < kanzure> do you not love me?
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18:33 < ebowden> I did read it.
18:34 < ebowden> APP (Alzheimer's)
18:34 < ebowden> "More than 50 different mutations in the APP gene can cause early-onset Alzheimer disease, which begins before age 65."
18:34 < ebowden> Amyloid precursor protein
18:35 < ebowden> It did not mention mutants with lower risk.
18:37 < ebowden> kanzure, ^
18:38 < ebowden> https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740882/pdf/373.pdf
18:38 < ebowden> THIS amused me.
18:45 < rpifan> ebowden, direct drive is better
18:53 < nmz787> we should genetically knock-out the knee-jerk reaction
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19:31 < nmz787> hmm, U.S. units are /not/ Imperial
19:31 < nmz787> .wik Comparison_of_the_imperial_and_US_customary_measurement_systems
19:31 < yoleaux> "Both the imperial and United States customary systems of measurement derive from earlier English systems used in the Middle Ages, that were the result of a combination of the local Anglo-Saxon units inherited from German tribes and Roman units brought by William the Conqueror after the Norman Conquest of England in 1066." — https://en.wikipedia.org/wiki/Comparison_of_the_imperial_and_US_customary_measurement_systems
19:32 < nmz787> "At one time the definition of the nautical mile was based on the sphere whose surface is the same as the Clarke Ellipsoid. In the US, the full value of 1853.256 metres was used, but in the Commonwealth, this was rounded to 6080 feet (1853.184 m). These have been replaced by the international version, which rounds the sixtieth part of the 45° to the nearest metre, as 1852 metres."
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19:50 < ebowden> A mutation (A673T) in the APP gene protects against Alzheimer’s disease. This substitution is adjacent to the beta secretase cleavage site and results in a 40% reduction in the formation of amyloid beta in vitro.[
19:50 < ebowden> \:D/
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20:53 < ebowden> kanzure, ^
20:54 < ebowden> (From the wikipedia article.)
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--- Log closed Sat Nov 25 00:00:25 2017