--- Log opened Thu Dec 14 00:00:58 2023
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13:56 < ike8> I don't have access to the paper, but MIB-626 looks interesting.
13:56 < ike8> > MIB-626 treatment was associated with substantial dose-related increases in blood NAD levels
13:56 < ike8> https://pubmed.ncbi.nlm.nih.gov/35182418/
14:46 < docl> Here's an open access article mentioning the substance https://www.sciencedirect.com/science/article/pii/S2161831323013595
14:50 < docl> Here's another that summarizes it https://link.springer.com/article/10.1007/s11357-022-00705-1
14:50 < docl> > An RCT with 1000 and 2000 mg/day oral doses of MIB-626, a unique microcrystalline NMN formulation, on 32 overweight or obese older adults showed that blood NAD concentration was dose-dependently increased and NMN treatment was also safe and well tolerated, but the trial found that lower doses failed to significantly elevate blood NAD concentration
15:09 < Ashstar> Yes, too bad NMN is ridiculously expensive!
15:11 < Ashstar> I guess only the wealthy can afford these life extension substances, while the rest of us just have to eat healthy
15:13 < L29Ah> pretty sure it'll get much cheaper in three years
15:14 < L29Ah> https://www.iherb.com/pr/california-gold-nutrition-nmn-powder-300-mg-1-05-oz-30-g/112136 oh it's on iherb now, already much cheaper than it was a couple of years ago
15:15 < Ashstar> yeah, a Kg of NMN was thousands of $
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16:46 < ike8> I thought there was new data showing that regular NMN doesn't increase NAD levels
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18:23 < hprmbridge> Eli> You can also just take niacin
18:35 < hprmbridge> kanzure> connectome memory decoding https://braininspired.co/podcast/180/
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19:03 < docl> https://www.centauri-dreams.org/2016/08/03/antimatter-production-harvesting-in-space/
19:03 < docl> > Jupiter is a source, but Saturn is even better, for a larger flux enters its atmosphere. Saturn is, in fact, the place where the largest total supply of antiprotons appears, with reactions in its rings injecting 250 micrograms per year into the planet’s magnetosphere.
19:07 < docl> doesn't really seem likely to be all that profitable to harvest at that rate
19:11 < docl> otoh maybe there's a scheme you could use to make it speed up -- big solar mirrors that accelerate microscopic particles to collide with the rings at relativistic velocities, similar to some of the interstellar propulsion schemes?
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19:55 < docl> maybe just release aerographite macrons near the sun. the light pressure would accelerate them continuously from there. point the stream at Saturn and collect the resulting antimatter
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20:41 < Ashstar> hprmbridge, there are several form of niacin. the amide, the acid
20:41 < Ashstar> few others
20:41 < Ashstar> nicotinic acid amide
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20:42 < Ashstar> yes, niacin, the acid is great
20:42 < Ashstar> way to screw with someone
20:43 < Ashstar> causes your plateletes to flow through capialries
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20:43 < Ashstar> capilaries
20:43 < Ashstar> so one gets a skin flow of blood
20:43 < Ashstar> people freak out
20:45 < Ashstar> still NMN, has a great effect on the NAD pathway synthesis
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22:30 < muurkha> hprmbridge is a bot; it can't understand what you're saying
22:32 < Ashstar> ic
22:33 < Ashstar> dispenses related information without a prompt
22:34 < muurkha> it's a bridge
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--- Log closed Fri Dec 15 00:00:59 2023