--- Log opened Sat Mar 08 00:00:38 2025
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07:54 < kanzure> https://www.scattered-thoughts.net/writing/the-program-is-the-database-is-the-interface/
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17:08 < fenn> AI generated GLP-1 peptide has results like semaglutide ("BRP" based on its parent prohormone, BPM/retinoic acid inducible neural specific 2, or BRINP2-related peptide)
17:08 < fenn> .t https://med.stanford.edu/news/all-news/2025/03/ozempic-rival.html
17:08 < saxo> Naturally occurring molecule rivals Ozempic in weight loss, sidesteps side effects
17:26 < hprmbridge> kanzure> "yeah the problem is that they use a 100x higher dose than semaglutide and it only lasts a few hours. Someone will spend a few years modifying it to last longer, but I doubt it'll be any better than retardutide or some of the other stuff already in trials"
17:34 < fenn> sounds like yashgaroth
17:34 < fenn> can't patent a naturally occurring peptide right? better fluorinate the hell out of it
17:43 < fenn> i believe the B in BRINP2 comes from Bone Morphogenetic Protein, a signaling pathway
17:44 < fenn> BPM was a typo it should be BMP
17:51 < fenn> .t https://www.nature.com/articles/s41586-025-08683-y
17:51 < saxo> Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide | Nature
17:51 < fenn> (the paper)
17:53 < fenn> "Mechanistically, BRP administration triggers central FOS activation and acts independently of leptin, GLP-1 receptor and melanocortin 4 receptor."
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18:30 < hprmbridge> kanzure> "What's your dream list of CAD features?"
18:31 < hprmbridge> kanzure> I told him: API. SDK. open source. STEP import export. Solidworks file import export. Low memory. Fast rendering. Parametric modeling, constraints, constraints satisfaction engine. Parameterizable surface intersection resolution and tesselation resolution. Hierarchical component tree or graph. Undo history or equivalent. 2d hand sketch -> 3d model. CNC gcode generator, gcode simulator. Well
18:31 < hprmbridge> kanzure> written maintainable portable code.
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--- Log closed Sun Mar 09 00:00:39 2025