--- Log opened Mon Aug 18 00:00:13 2025
07:10 < hprmbridge> kanzure> x.com has been arguing about embryo selection because of orchid and herasight lately. and ultimately this particular argument is sourcing entirely from religious people, not lefties this time.
07:11 < hprmbridge> kanzure> i'm curious what their endgame is here. it's a religious disagreement. are they willing to go to war over IVF and abortion? what's the plan exactly?
07:12 < hprmbridge> kanzure> If I read one more tweet from a midwit religious adherent "Hey did you know this is IMMORAL? You probably have never heard this perspective before!" one more time, I'm going to lose my mind. Their default assumption seems to be that we are totally unaware of religious arguments. What a wild assumption to make. Crazy.
07:13 < hprmbridge> kanzure> vitalik stepped in to scold the technologists by saying we are somehow going to impose eugenics on everyone and we need to commit to not doing that (even though the detractors are doing precisely that to marginalize tech innovators).
07:13 < hprmbridge> kanzure> https://x.com/kanzure/status/1957303975645950106
07:15 < L29Ah> it is time to weaponize LLMs
07:17 < L29Ah> seems like vitalik is very careful about political stuff, apparently he feels his physical/financial position being very fragile and sensitive to the powers that are, so he doesn't touch political things and only criticizes stuff from a noncommittal centrist pov
07:19 < kanzure> okay well it's not very centrist of him to propose that the religious fundamnentalists get to block tech development and claim moral high gronud
07:19 < L29Ah> but given his blog he is apparently thinking a lot about decentralization, including governance problems
07:19 < kanzure> ground.
07:20 < kanzure> there is probably a good writer out there who has disentangled the post-ww2 mythos sufficiently to cut through these problems. i don't have the time or inclination to go find them.
07:21 < L29Ah> in your quote he specifically argues for "live and let live", but i'm probably missing context (and he might have as well)
07:24 < kanzure> he is arguing for "live and let live" from the pro-embryo-selection people; i do not see a call from him that the anti-technologists must adopt "live and let live".
07:27 < kanzure> https://x.com/tracewoodgrains/status/1957258405191590332 https://x.com/tracewoodgrains/status/1957268191693988045
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07:45 < jrayhawk> apache is violating spec by serving text/markdown without a charset
07:47 < jrayhawk> I just fixed it
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07:58 < kanzure> good speech from bitstein about the importance of knowing the purpose of arguing on the internet https://diyhpl.us/wiki/transcripts/bit-block-boom/2019/how-to-meme-bitcoin-to-the-moon/
08:01 < kanzure> just identifying and labeling the origin of those moral perspectives is probably of high utility, it may not be obvious to onlookers that this is mostly argumentation that is religious in origin. i dunno.
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08:36 < RangerMauve> BTW the optical mouse on the twiddler is exactly what I expected and is decent. Still need to learn how to type on this thing but the software for it is easy enough to grasp, just need to practice
08:37 < L29Ah> great, thanks
08:37 < RangerMauve> I went to the grocery store with my Viture plugged into my phone and practiced while my partner got stuff, so it's a pretty comfy setup
08:37 < L29Ah> did you try grabbing things with your typing hand, or it is only good for poking?
08:38 < RangerMauve> If I get comfy enough that I can code on this thing I'm gonna replace my compute with one of these: https://www.khadas.com/edge
08:38 < RangerMauve> It was pretty easy to hold a drink along with the twiddler or grab a grocery bag
08:38 < L29Ah> if i do, i will get a Framework 13 mobo
08:38 < RangerMauve> I have pretty long fingers though sop YMMV
08:38 < L29Ah> RK3588 kinda sucks
08:39 < RangerMauve> Yeah I'm mostly in it for the form factor and battery usage
08:39 < L29Ah> but perhaps good enough if you aim for a smartphone replacement
08:40 < RangerMauve> Most of my heavy compute these days is for ML inference so I was thinking of getting additional dedicated boxes to stap to my body's local network for when I need them
08:40 < RangerMauve> Like "progressive enhancement"
08:41 < RangerMauve> IF it's too painful I'm also gonna go with the f13 mainboard with this battery holder: https://www.printables.com/model/1051364-framework-13-mainboard-case-with-battery
10:38 < hprmbridge> kanzure> "its lacking detail on how to make the hair follicles individually addressable no"
10:39 < hprmbridge> nmz787> RangerMauve: what viture do you have? I was gonna return the Luma Pro I got
11:26 < RangerMauve> nmz787 Viture XR Pro, but I kinda want to switch to the XReal One Pro with the camera attachment because I'm missing the mic/camera setup.
11:30 < RangerMauve> kanzure 😅 FWIW I'd be happy to use whatever system gets developed even if it's worse than EMG
11:36 < hprmbridge> nmz787> ah, someone on reddit was saying their XR pros were better than the Luma Pros
11:36 < hprmbridge> nmz787> I was eyeing a XR pro + mobile dock on ebay from their refurb store, but I still don't know if they'll be more than a cool gizmo
11:37 < hprmbridge> nmz787> the spacewalker program cannot disable perspective distortion
11:37 < hprmbridge> nmz787> and IDK if I want to cobble together my own ripoff of spacewalker
11:37 < RangerMauve> IMO the built in 3DOF chip means the software on your device itself is less important
11:38 < RangerMauve> No need to space walker if you're fine with one large 3dof tracked monitor 🤷
11:38 < hprmbridge> nmz787> I just want 3 "displays" and turning my head simply moves the screens left or right, with no distortion to add aliasing to text
11:38 < RangerMauve> Right, yeah custom software would be ned
11:39 < hprmbridge> nmz787> dealing with double-click to maximize a screen when you have 1 giant display is really the main reason I was thinking of using spacewalker... also I didn't see any way to make a huge display without that program
11:39 < hprmbridge> nmz787> (unless you're referring to xreal one pro)
11:39 < RangerMauve> Real One Pro, yeah
11:40 < RangerMauve> I use this to make it easier to do horizontal window switching: https://github.com/YaLTeR/niri
11:40 < RangerMauve> This has been making progress towards making setups like "Give me three surfaces to render wayland sessions", but it's pretty manual with zero docs
11:40 < RangerMauve> https://stardustxr.org/
11:41 < hprmbridge> nmz787> ah. not compatible with windblows
11:41 < RangerMauve> I played a bit with getting that sort of setup in the Godot game engine but I've put it on pause
11:41 < RangerMauve> Ah, yeah IDK about windows sadly 😅
11:49 < hprmbridge> nmz787> I found some "virtual display driver" stuff that is open source... so I have a feeling I'd just need a GUI program running on the glasses display, that is sourcing it's data from the virtual displays, and selectively blitting data from them based on the IMU in the glasses
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11:58 < RangerMauve> I think the main issue is you need the GUI renderer to be aware of the 3d transform to make the text readable. SimulaVR had some decent writeups on the problem IIRC. https://simulavr.com/
11:58 < RangerMauve> https://github.com/SimulaVR/Simula?tab=readme-ov-file#text-quality
11:59 < RangerMauve> FWIW I've been happy with having a non-spatial desktop without 3DOF and keyboard shortcuts to switch between workspaces instead of virtual monitors
12:00 < hprmbridge> nmz787> I don't want ANY 3d transformation
12:00 < RangerMauve> Oh oh. Then just plug it in like a monitor and use virtual desktop switching. Easy as
12:01 < hprmbridge> nmz787> I suppose kb shortcuts could work, but it's more keystrokes/mental-subroutines to remember
12:01 < RangerMauve> You can make code to listen to the accelerometer for head gestures too
12:01 < hprmbridge> nmz787> the luma pros don't have an SDK (yet?)
12:01 < hprmbridge> nmz787> and they never released it for windows either
12:03 < RangerMauve> I'd be surprised if the accelerometer profile changed. They're usually reusable between generations of headsets. e.g. https://github.com/boomskats/woahland
12:03 < hprmbridge> nmz787> but I really would like a sliding experience, not just whole virtual desktop switch-out
12:04 < RangerMauve> Sliding but no 3d transform seems doable. PRobs would be good if you could get the effect working with just a scrollwheel based gesture first before investing in VR
12:04 < RangerMauve> I have sliding working via niri for example 😸
12:05 < hprmbridge> nmz787> it seems like such a simple feature to add to spacewalker
12:05 < hprmbridge> nmz787> some checkbox to "disable perspective distortion"
13:19 < hprmbridge> kanzure> "Spatially precise genetic engineering at the electrode-tissue interface" https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202401327
13:20 < hprmbridge> kanzure> "Specifically, ultraflexible neural electrodes with short hairpin RNAs (shRNAs) designed to silence the expression of endogenous genes within neural tissues are combined. The system facilitates shRNA-mediated knockdown of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and polypyrimidine tract-binding protein 1 (PTBP1), two essential genes associated in neural survival/growth and
13:20 < hprmbridge> kanzure> neurogenesis, within specific cell populations located at the electrode-tissue interface. Additionally, it is demonstrated that the downregulation of PTEN in neurons can result in an enlargement of neuronal cell bodies at the electrode-tissue interface."
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13:28 < hprmbridge> kanzure> but how does it achieve long-term expression of those shRNA molecules?
13:33 < hprmbridge> kanzure> "Coating of cochlear implant electrodes with bioactive DNA-loaded calcium phosphate nanoparticles for the local transfection of stimulatory proteins" https://pubmed.ncbi.nlm.nih.gov/34280824/
13:45 < hprmbridge> kanzure> other RNA local delivery techniques https://pmc.ncbi.nlm.nih.gov/articles/PMC4665980/
14:29 < hprmbridge> kanzure> https://www.tinytpu.com/
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14:57 < hprmbridge> kanzure> "Flat cell imaging" https://arxiv.org/abs/2411.12656
14:58 < hprmbridge> kanzure> "We present a method for flattening live cells to a thickness of down to 200 nanometers by confining them between two surface-treated transparent plates. The anti-fouling coating on the surfaces restricts the cells to a quasi-two-dimensional space by exerting osmotic control and preventing surface adhesion. This technique increases the distance between cellular components, thereby enabling high-
14:58 < hprmbridge> kanzure> resolution imaging of their spatio-temporal dynamics. The viability and phenotype of various cell types are demonstrated to be unaltered upon release from flat-cell confinement."
14:58 < hprmbridge> kanzure> but isn't this just a normal microscopy cover slip technique?
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15:13 < hprmbridge> kanzure> "Large-scale single-neuron speech sound encoding across the depth of human cortex" https://www.nature.com/articles/s41586-023-06839-2
15:13 < hprmbridge> kanzure> note that this is different from the paper recently mentioned in here about producing speech via neuronal interface (no mouth flap movements required); this one is listened speech decoding.
15:16 < RangerMauve> Jeeze. Maybe we'll get digi brains in our lifetimes after all
15:35 < L29Ah> i doubt normal microscopy cover slip goes down to under 10um gap width
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18:54 < hprmbridge> kanzure> https://jax-ml.github.io/scaling-book/
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--- Log closed Tue Aug 19 00:00:14 2025