--- Log opened Tue Aug 19 00:00:14 2025
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04:15 < hprmbridge> kanzure> "A primer to directed evolution: current methodologies and future directions" https://pmc.ncbi.nlm.nih.gov/articles/PMC10074555/ (2023)
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07:08 < hprmbridge> kanzure> https://research.nvidia.com/labs/adlr/NVIDIA-Nemotron-Nano-2/
07:29 < kanzure> it would be fun to look at physarum polycephalum slime mold (throughout its life cycle) in the flat cell imaging cellular confinement microscope.
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07:30 < kanzure> "In vivo femtosecond laser nanosurgery of the cell wall enabling patch-clamp measurements on filamentous fungi" https://www.nature.com/articles/s41378-024-00664-x (2024)
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07:41 < kanzure> "Design of an automated robotic microinjection system for batch injection of zebrafish embryos and larvae" https://www.nature.com/articles/s41378-023-00645-6 (2024)
07:42 < kanzure> cool, automated batch microinjection of embryos.
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11:01 < hprmbridge> kanzure> wow this is so poorly written and imagined, geeze https://ai-pathways.existentialhope.com/wp-content/uploads/2025/08/The-d_acc-pathway.pdf
11:02 < L29Ah> .t https://www.lifespan.io/news/an-overly-youthful-immune-system-might-cause-autoimmunity/
11:02 < saxo> An Overly Youthful Immune System Might Cause Autoimmunity
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17:48 < hprmbridge> kanzure> "Polyethylene glycol fusion for nerve repair" https://www.jhsgo.org/article/S2589-5141%2824%2900031-8/fulltext (2024)
17:58 < hprmbridge> kanzure> this article contains a review of clinical trials for cell replacement therapies for spinal cord injury https://pmc.ncbi.nlm.nih.gov/articles/PMC11005494/ (2024)
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19:33 < hprmbridge> kanzure> "Walking naturally after spinal cord injury using a brain–spine interface" https://www.nature.com/articles/s41586-023-06094-5
19:33 < hprmbridge> kanzure> kind of odd that turning it off doesn't change motor control; seems like the injury was not complete section?
20:21 < hprmbridge> kanzure> "Imaging and nanodissection of individual supercoiled plasmids by atomic force microscopy" https://pmc.ncbi.nlm.nih.gov/articles/PMC310406/ (1992)
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21:57 < hprmbridge> kanzure> "Interspecies mitochondrial fusion between mouse and human mitochondria is rapid and efficient" https://pmc.ncbi.nlm.nih.gov/articles/PMC2693707/ (2009)
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21:58 < hprmbridge> kanzure> xenomitochondria!
22:00 < hprmbridge> kanzure> "Xenotransplantation of mitochondria: A novel strategy to alleviate ischemia-reperfusion injury during ex vivo lung perfusion" https://www.jhltonline.org/article/S1053-2498(24)01938-7/fulltext
22:02 < hprmbridge> kanzure> or this xenomitochondrial doping article for brain function https://journals.sagepub.com/doi/10.3727/096368915X689785?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org
22:07 < hprmbridge> kanzure> "Improvement of cognitive and motor performance with intravenously injected mitochondria mitotherapy in aged mice" https://pmc.ncbi.nlm.nih.gov/articles/PMC7019143/
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23:24 < hprmbridge> .monokhrome> What happened with that project to move the 13 mitochondrial genes to the nucleus?
23:35 < jrayhawk> "the"?
23:44 < jrayhawk> do you mean the subset of the electron transport chain that's encoded in 13 of the 37 human mitochondrial genes? https://academic.oup.com/bmb/article/106/1/135/323715#4376867
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--- Log closed Wed Aug 20 00:00:15 2025