--- Log opened Sat Aug 23 00:00:18 2025
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05:17 < hprmbridge> kanzure> "Alterations in tRNA abundance and modification, linking codon optimality, impact mRNA stability and protein output in a codon-dependent manner, suggesting tRNA as a potential translation enhancer. Here, we report a strategy named tRNA-plus to augment translation via artificially modulating tRNA availability. Overexpression of specific tRNAs enhances the stability and translation efficiency ...
05:17 < hprmbridge> kanzure> Additionally, chemically synthesized tRNAs bearing multiple site-specific modifications, particularly at the anticodon-loop and TΨC-loop, exhibit on average ~4-fold higher decoding efficacy than unmodified tRNAs, along with increased stability and reduced immunotoxicity. ... codelivery of tRNA through lipid nanoparticles." https://www.nature.com/articles/s41467-025-62981-7
05:21 < hprmbridge> kanzure> https://reprap.org/wiki/RepRapMicron https://github.com/VikOlliver/RepRapMicron
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07:08 < hprmbridge> docl> Was watching this video about how rubber tree blights are a major systemic risk, since synthetic rubber doesn't quite have the same properties.
07:08 < hprmbridge> docl> https://www.youtube.com/watch?v=AFXLZ7FEJc4
07:08 < hprmbridge> docl> I wonder why they don't just put rubber tree or guayule plant genes in brewer's yeast and synthesize it in big bioreactors? Are bioreactors that much more expensive than trees?
07:16 < hprmbridge> docl> Addgene has a few matches for latex plasmids.
07:16 < hprmbridge> docl> https://www.addgene.org/search/catalog/plasmids/?q=latex
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07:53 < hprmbridge> docl> https://2016.igem.org/Team:Stanford-Brown/SB16_BioMembrane_Latex
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09:03 < hprmbridge> kanzure> rdiffusion and other protein design services, charged per jobhttps://subseq.bio/
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09:14 < L29Ah> .t https://slate.com/technology/2025/08/millennials-gen-z-death-rates-america-high.html
09:14 < saxo> Millennials are dying at an alarming rate. We have a few ideas as to why.
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10:06 < superkuh> "today’s postpandemic vantage point" only from a certain point of view. Still seems to be going to me.
10:06 < superkuh> If you go by numbers instead of feels.
10:07 < hprmbridge> docl> I wonder how hard it would be to get latex-bearing potatoes? Or whatever the market wants the most (maybe spider silk protein, why not)
10:08 < superkuh> Oh. I think that article might be written by AI? "In the 2028 election, millennial and Gen Z voters will account for half of the U.S. electorate."
10:14 < L29Ah> MuaddibLLM: what do those bullshit labels even mean? look like humanities slop to me
10:14 < MuaddibLLM> L29Ah: They’re just fuzzy birth-year cohorts used by demographers and marketers to talk aggregate cohort effects, not hard science, with arbitrary US-centric cutoffs (think Millennials ~1981-96, Gen Z ~1997-2012), and they’re usually worse than asking for age, income, region, and context.
10:15 < L29Ah> MuaddibLLM: what portion of US voters will millenials and gen Z become at year 2028?
10:15 < pasky> MuaddibLLM: what comes after gen z? i always forget ...
10:15 < MuaddibLLM> hang on, pulling real 2028 electorate numbers from Pew/Census so I don’t BS you
10:15 < MuaddibLLM> L29Ah: According to the Slate article superkuh mentioned, Millennials and Gen Z will account for half (50%) of the US electorate in 2028 - pasky: Generation Alpha comes after Gen Z (born roughly 2010-2025).
10:16 < MuaddibLLM> digging deeper for actual Pew/Census projections since that Slate claim needs verification
10:16 < MuaddibLLM> L29Ah: According to Governing.com projections, millennials + Gen Z will make up "over half" of the US voting population by 2028 (they hit 48.5% by 2024), so that Slate article's "half" claim is roughly accurate - https://www.governing.com/now/how-much-could-younger-voters-affect-future-election-outcomes
10:16 < L29Ah> MuaddibLLM: after Z comes O, for ZOV
10:16 < pasky> hm i wonder how can i organize the chat history better for less mixups..
10:16 < MuaddibLLM> L29Ah: heh, cute, but the unofficial naming after Z is Gen Alpha (born ~2010-2024) then likely Gen Beta for 2025+ - at least until marketers rename it again.
10:22 < L29Ah> i think it missed some of the requests
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10:50 < hprmbridge> kanzure> https://ualinkconsortium.org/
10:56 < hprmbridge> Katylase> `hi friends!`
10:56 < hprmbridge> Katylase> `Query: how are you doing today?`
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11:31 < pasky> L29Ah: it didn't, it just generated a second answer to you when prompted with mine
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12:39 < hprmbridge> kanzure> oh rfdiffusion2 is finally available https://github.com/RosettaCommons/RFdiffusion2
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12:52 < hprmbridge> nmz787>  https://cdn.discordapp.com/attachments/1064664282450628710/1408901700458250241/PXL_20250823_190435057.jpg?ex=68ab6d75&is=68aa1bf5&hm=b2a2df1c23e7208f1154873df9111ac8acd369168165bda1471c51f82380a0a5&
12:52 < hprmbridge> nmz787> @Katylase doing hikes
13:28 < hprmbridge> kanzure> flash attention https://gau-nernst.github.io/fa-5090/
13:46 < hprmbridge> Katylase> `cool! i LOVE the froggy`
13:47 < hprmbridge> Katylase> Rosetta let's GO!!!^^
13:56 < hprmbridge> kanzure> katylase how many cycles around the sun have you had in total?
14:12 < hprmbridge> Katylase> 20, (21 soon),why?
14:13 < hprmbridge> Katylase> 20, (21 soon),why?
14:15 < hprmbridge> kanzure> befuddling, nonsense.
14:18 < hprmbridge> Katylase> did i say something wrong?
14:20 < hprmbridge> kanzure> https://huggingface.co/xai-org/grok-2
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14:29 < hprmbridge> Katylase> @kanzure i have a question...
14:29 < hprmbridge> Katylase> am i weird for finding alphafold relatable?
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16:17 < L29Ah> .t https://youtu.be/9alJwQG-Wbk
16:17 < saxo> Neuromuscular Aim Assist