--- Log opened Fri Sep 05 00:00:31 2025
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08:42 < kanzure> hmph
08:54 < kanzure> "Extracorporeal placental support in a sheep's gravid uterus" https://www.biorxiv.org/content/10.1101/2025.07.02.662865v1
08:55 < kanzure> "Ex utero monkey embryogenesis from blastocyst to early organogenesis" https://www.cell.com/cell/fulltext/S0092-8674%2823%2900416-6
08:55 <+gnusha_> https://secure.diyhpl.us/cgit/diyhpluswiki/commit/?id=98971716 Bryan Bishop: artificial womb refs >> http://diyhpl.us/diyhpluswiki/artificial_womb/
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11:23 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1413590469585277009/get_attachment_url.png?ex=68bc7c37&is=68bb2ab7&hm=283c13a7b6fbd52d0379b7c3a2a84e5f0cf51a941ddcd3b72696b55bea8f36f9&
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11:40 < hprmbridge> kanzure> placenta anatomy https://cdn.discordapp.com/attachments/1064664282450628710/1413594626035814410/65dfaec238e93ca2da6d7516_V2_1707152275926_1da774ca-e423-4bf7-bfef-e4708516df43_HIGH_RES.png?ex=68bc8016&is=68bb2e96&hm=5c9f3ec9efbe0202a5390ea2953440786b8a6c444d0a1d16e5ffbc643c4291dc&
11:44 < hprmbridge> Eli> https://media.nature.com/lw767/magazine-assets/d41586-023-02901-1/d41586-023-02901-1_26040880.gif?as=webp
11:48 < kanzure> the circuit diagram is more helpful because the lamb biobag image doesn't tell you what they are doing
11:52 < hprmbridge> lordkek__> Kanzure Can you help me finish cold fusion concept
11:52 < hprmbridge> lordkek__>
11:52 < hprmbridge> lordkek__> (where the money from the profits would be donated to p2pfoundation)
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12:20 < kanzure> "First live birth after uterine transposition" https://www.fertstert.org/article/S0015-0282(23)00166-8/fulltext (2023)
12:21 < kanzure> "[We] report the first case of live birth of a child after uterine transposition, pelvic radiotherapy, and subsequent uterine repositioning."
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12:32 < kanzure> "doses of less than 2 Gy are associated with up to 50% oocyte damage, and doses greater than 14 Gy result in ovarian failure [15]... This is important because most treatment plans for pelvic radiotherapy are typically prescribed at doses of 45 Gy or more [14]." from https://pmc.ncbi.nlm.nih.gov/articles/PMC11432366/
12:33 < kanzure> "One of the earliest documented cases of ovarian preservation prior to pelvic RT by means of surgical suspension was described by Batten and Brown in 1958 [16]. This was a case of a young, eight-year-old female with a large pelvic neuroblastoma. At the time of laparotomy for tumor resection, it was planned to move the ovaries out of the radiation field and protect them with two separate ...
12:34 < kanzure> ...walnut-shaped latex-coated 2 mm thick lead sheaths with a hole for the fallopian tube and broad ligament. Each ovary had a separate sheath that was then secured together and sutured to the anterior parietal peritoneum as high as possible. Two months after the completion of radiation treatment, a second laparotomy was performed to remove the lead sheaths. [..] Years after her treatment, the ...
12:34 < kanzure> ...patient was menstruating regularly indicating intact ovarian function [16]."
12:34 < kanzure> "There are variations in the surgical technique for ovarian transposition. Traditionally, the ovaries can be transposed either medially or laterally. In the former, the ovaries are fixed behind the uterus which acts as a shield from radiation." ummm
12:38 < kanzure> "Successful human ovarian autotransplantation to the upper arm" https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.20715 (2004) 
12:41 < kanzure> "A new technique to protect ovarian function before pelvic irradiation: Heterotopic ovarian autotransplantation" https://pubmed.ncbi.nlm.nih.gov/3440230/ (1987) this seems to be the first report of the technique; the previous article (above) is more interesting.
12:44 < kanzure> which describes that study as: " humans, one study has been described in which the ovary has been grafted into the medial aspect of the left arm. Before anastomosing the ovarian vessels to the humeral vascular bundle, the skin was expanded by implanting a testis prosthesis subcutaneously."
12:45 < kanzure> "Using laparoscopy, ovarian cortical strips were placed either beneath the pelvic peritoneum of the ovarian fossa or in the forearm or abdominal wall as the transplant recipient site. Endocrine function was established and follicle growth observed, resulting in oocyte retrieval in one patient without fertilization. A recent attempt after transplanting ovarian cortical strips to the abdominal ...
12:45 < kanzure> ...wall resulted in oocyte retrieval, fertilization, and normal development into a four-cell embryo. These results are promising with regards to the reestablishment of cyclic function and even fertility after simple implantation without vascular anastomosis. However, a substantial number of follicles are lost during graft establishment, amounting to 70–75% of the follicle reserve. Ischemia, ...
12:45 < kanzure> ...which is a critical factor in follicular loss, is a major limiting factor that has been shown to affect primordial follicle survival in the transplanted graft. To overcome these limiting factors, whole ovary tissue specimens have been transplanted by means of vascular anastomoses. In humans, one study has been described in which..." (as above)
12:57 < kanzure> intraovarian and intrafollicular injection could be greatly facilitated by human ovarian autotransplantation to the arm.... in theory this could be done via in-patient procedure for normally positioned ovaries but it looks like the IVF people don't do regular intrafollicular injection, possibly because of the inconvenience. there was an article posted in here a few weeks ago where, during ...
12:57 < kanzure> ...oocyte retrieval, one study found that there is a benefit of also intraovarian dosing to start the next cycle. although subsequent injections were not intraovarian in nature.
12:59 < kanzure> ultrasound-guided percutaneous aspiration of forearm ovaries or forearm follicles in ovarian cortical strips doesn't seem like that bad of an egg retrieval procedure
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15:55 < hprmbridge> kanzure> "Live birth after cervical ectopic uterus transplantation in mice" https://pubmed.ncbi.nlm.nih.gov/32092213/ using the jugular.
15:57 < hprmbridge> kanzure> "A rat model of pregnancy in the male parabiont" https://www.biorxiv.org/content/10.1101/2021.06.09.447686v2.abstract
15:57 < hprmbridge> kanzure>  https://cdn.discordapp.com/attachments/1064664282450628710/1413659377855893524/image0.jpg?ex=68bcbc64&is=68bb6ae4&hm=1c7a499e60926dbc845c9d6a5d4a9f641a0c41463386965b57cebf1024412210&
16:02 < hprmbridge> kanzure> "To our knowledge, pregnancy has never been reported in male mammalian animals"
16:03 < hprmbridge> kanzure> but... it's permanent parabiosis with a female. is this supposed to be remarkable that a male survived uterus transplantation?
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18:28 < hprmbridge> kanzure> "Enhanced learning and memory in patients with CRB1 retinopathy" https://www.mdpi.com/2073-4425/15/6/660
18:28 < hprmbridge> kanzure> reminds me of the RIMS1 blindness/intelligence thing.
18:31 < hprmbridge> kanzure> "The human cognition-enhancing CORD7 mutation increases active zone number and synaptic release" https://academic.oup.com/brain/article/145/11/3787/6505110 here is a drosophila electrophysiology study of the RIMS1/RIM1 mutation.
18:35 < hprmbridge> kanzure> "a later re-analysis of the same ophthalmic pedigree concluded the retinal disease was explained by PROM1, casting doubt on the original assignment of the ocular phenotype to RIMS1"
18:37 < hprmbridge> kanzure> "Identification of a unique, de novo MYCBP2 variant in an individual with highly superior autobiographical memory" https://www.medrxiv.org/content/10.1101/2024.12.18.24319147v1
18:38 < hprmbridge> kanzure> "Using whole exome sequencing of the HSAM individual and their unaffected parents, we identified a unique de novo missense variant in MYCBP2, which encodes an E3 ubiquitin-protein ligase. To explore the potential behavioral consequences of this variant, we introduced the homologous variant into C. elegans, which resulted in reduced forgetting and increased membrane-bound glutamate receptor in
18:38 < hprmbridge> kanzure> relevant neuronal cells."
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21:32 < fenn> "Currently, medical tourism suffers from being scattered, disorganized, hard to penetrate, to perform discovery, to determine quality. If that industry grows tenfold in size in the transition from therapies for very sick people, a small fraction of the population, to enhancement therapies that can be applied to nearly everyone, many of these challenges will likely be addressed"
21:32 < fenn> -- Reason, CEO of Repair Biotechnologies
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--- Log closed Sat Sep 06 00:00:31 2025