--- Log opened Wed Sep 24 00:00:49 2025
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01:36 < fenn> this small vision LLM is quite good and could potentially run on a phone or robot https://huggingface.co/PerceptronAI/Isaac-0.1
01:37 < fenn> it struggles with faces and characters, and gets bizarre situations wrong sometimes
01:37 < fenn> very good at OCR though
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04:14 < fenn> neurips (NIPS) has nearly 6000 posters this year https://neurips.cc/Downloads/2025
04:16 < hprmbridge> kanzure> i clicked one, it's boyden https://neurips.cc/virtual/2025/poster/121838
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04:56 < fenn> showing the relative strengths and weaknesses of human vs AI on "long-context problems requiring deep understanding and reasoning" https://fennetic.net/irc/longbench_plot_radar.png
04:58 < fenn> oh, right. interactive version: https://fennetic.net/irc/longbench_plot_radar.html
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06:33 < L29Ah> > Mediterranean diet was superior to the low-fat diet in preventing major cardiovascular events
06:35 < fenn> but did they try the potato diet
06:39 < jrayhawk> the sterol-bound-membrane-disrupting glycoalkaloid diet? well, we do have the one case report
06:45 < jrayhawk> meanwhile, even the most naive of mesa-alignment diets beat out the mediterranean diet on leptin sensitivity: https://link.springer.com/article/10.1186/1743-7075-7-85 https://link.springer.com/article/10.1186/s12933-016-0398-1 and insulin sensitivity: https://link.springer.com/article/10.1007/s00125-007-0716-y
06:46 < jrayhawk> oh, no, i was confusing seth roberts with the potato diet guy, nevermind on the case report
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09:35 < kanzure> hmph
09:43 < kanzure> https://www.ucl.ac.uk/news/2025/sep/gene-therapy-appears-slow-huntingtons-disease-progression via stereotactic intracortical delivery of viral gene therapy to striatum
09:43 < kanzure> "The AMT-130 DNA becomes a permanent addition to the neuron. It contains a set of instructions for making a molecule of RNA which has been designed to bind to the RNA that is produced when a cell is making the huntingtin protein. When AMT-130 RNA binds to the cell’s own huntingtin RNA, it summons an enzyme to destroy it. As a result, the huntingtin message is deleted and less of the protein ...
09:44 < kanzure> ...is made – permanently.
09:46 < kanzure> i wonder how they decided on intracortical delivery of the virus. most people just do AAV delivery via circulatory system and hope it passes blood brain barrier?
09:47 < kanzure> 18 hour neurosurgery
09:49 < L29Ah> MuaddibLLM: is AMT a good psychedelic drug?
09:50 < MuaddibLLM> L29Ah: Short answer - not really; AMT (alpha-methyltryptamine) is potent and historically odd (sold as Indopan in the USSR), but it’s a very long, body-heavy, somewhat dirty tryptamine with MAOI-like interaction risks and significant legal/serotonin-syndrome hazards.
09:58 < kanzure> "Taking the knife to neurodegeneration: a review of surgical gene therapy delivery to the CNS" https://pmc.ncbi.nlm.nih.gov/articles/PMC10940433/
10:00 < kanzure> "intraparenchymal delivery" okay
10:02 < kanzure> "The AAV2-AADC intraputaminal delivery trial utilised the Clear Point Neuro-navigation system with the Smart flow© cannulae and markets itself as a cannulae specifically for intraparenchymal drug delivery [11, 12]. This system has the advantage that it allows real-time imaging of the gene therapy infusion allowing biodistribution to be assessed."
10:04 < kanzure> "One pre-clinical approach to improving intraparenchymal delivery without the need for an invasive approach is to utilise focused ultrasound to permeabilise the blood-brain barrier within a specific area in conjunction with peripheral vascular delivery of AAV within microbubbles. Rodent studies showed good biodistribution within the brain regions being targeted, caudate/putamen in this ...
10:04 < kanzure> ...example; however, as this involves reasonably high doses (1.2 × 1011vg) delivered into the peripheral vasculature, as expected, the liver, lung and heart were shown to express fluorescence [58]." huh? then why let the blood go to the liver? why not drain it before it gets there? you only need a short dose of ultrasound anyway...
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15:17 < hprmbridge> kanzure> " Automating the search for artificial life with foundation models" https://pub.sakana.ai/asal/
15:20 < hprmbridge> kanzure> https://www.hackaging.ai/#register
15:24 < hprmbridge> kanzure> "Automatic and accurate reconstruction of long-range axonal projections of single-neuron in mouse brain" https://elifesciences.org/articles/102840?utm_source=twitter&utm_medium=social&utm_campaign=organic
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16:02 < hprmbridge> kanzure> "The multiomics blueprint of the individual with the most extreme lifespan" https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00441-0 (2025)
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17:33 < hprmbridge> kanzure> "The mouse lymph node as an ectopic transplantation site for multiple tissues" https://europepmc.org/abstract/MED/23000933
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17:54 < hprmbridge> kanzure> https://www.nikonsmallworld.com/galleries/2025-small-world-in-motion-competition/live-65-hour-recording-of-rat-hippocampal-neuron-growth
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18:22 < hprmbridge> kanzure> "Transforming the spleen into a liver-like organ in vivo" https://www.science.org/doi/10.1126/sciadv.aaz9974
18:24 < hprmbridge> kanzure> interspecies blastocyst complementation for liver https://stemcellres.biomedcentral.com/articles/10.1186/s13287-021-02348-z kinda cool that these grew a liver organ!
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20:52 < hprmbridge> justanothercicadainspace> Hey, are there any newer research articles/finding related to scoliosis? would anyone here happen to know?
21:04 < jrayhawk> https://scholar.google.com/scholar?as_ylo=2021&q=scoliosis+AND+%28+etiology+OR+causes+%29
21:11 < jrayhawk> i have done zero study on the subject, but, offhand, i would be immediately suspicious of 1) human lack of prolase needed to proteolyze proline, and expression of direct intracellular intestinal transporters for collagen peptides, suggests that it may be a good idea to treat collagen as an essential nutrient 2) common deficiencies in retioids, vitamin D, and menatetrenone cause bone mineralization 
21:11 < jrayhawk> problems and also problems with the structural organization of collagen
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23:18 < fenn> in cow soy feed, "Rumen microbes isomerize and partially hydrogenate linoleic acid, to vaccenic/CLA intermediates: roughly 5–20%, 1–3% of dietary linoleic acid might be recovered as cis‑9,trans‑11 CLA in milk when feeding unprotected soy oil; using protected fats can raise that fraction several-fold (still usually <10–20% of dietary linoleic).
23:18 < fenn> Under typical feeding (unprotected soy oil or full‑fat soy), only a minority of dietary linoleic acid appears as CLA in milk because most is hydrogenated to stearic acid (C18:0)."
23:18 < fenn> "protection" means: Calcium salts of fatty acids, fat droplets coated with rumen‑stable material (e.g., formaldehyde‑treated protein or natural polymers) that resist microbial attack.
23:19 < fenn> i think we want them to attack though?
23:27 < fenn> imagine seeing milk in the store, "Now with added omega-6 fats!"
23:27 < fenn> added flax oil is almost as stupid though
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23:42 < fenn> "cheese: processors usually buy pooled milk from many farms. Pooling averages out farm‑level FA differences, so PUFA/MUFA in the milk will be near USDA/industry averages.
23:42 < fenn> Intentional enrichment is niche: only specialty or premium products (omega‑3‑enriched, high-CLA)"
23:43 < fenn> assuming the USDA average is up to date with the new insane farming practices
23:53 < fenn> i never knew about this "biohydrogenation" capability
--- Log closed Thu Sep 25 00:00:50 2025