--- Log opened Thu Sep 25 00:00:50 2025
02:08 < fenn> laser waterjet microjet engraving 5-Axis cutting compass cardinal sample in silicon carbide by Synova via superkuh (1min techno remix) https://www.youtube.com/watch?v=ry_Vuzw-ASM
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07:00 < kanzure> whisper has this interesting capability where if you speak for several words but give a certain kind of "stop", and then say something else, it understands that you intended to edit your previous words and it will perform that edit for you.
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07:01 < kanzure> which somehow "just works".. if i was talking to a human notetaker, i would probably instead switch my tone of voice or speak differently to make it clear to them that i am instructing them with a command instead of saying something for them to transcribe.
07:01 < kanzure> or, if i was in person, simply turning my head to look at them and do weird eyebrow communication would also do the trick... sometimes.
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09:58 < hprmbridge> jerlendds> https://ai.nejm.org/doi/abs/10.1056/AIoa2401033
09:58 < hprmbridge> jerlendds> > An Electrocardiogram Foundation Model Built on over 10 Million Recordings
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11:08 < kanzure> why would you want an electrocardiogram foundation model? is there predictive information available in the signal that isn't the standard rote memorization stuff that medicalpeoples train on?
11:49 < L29Ah> the memorization stuff is crude and binary-ish, machine learning can extract more intricate meanings that depend on lots of variables that only the most trained meatbags can capture
11:52 < L29Ah> wtf the paper is inaccessible!?
11:53 < L29Ah> ok it's https://arxiv.org/abs/2410.04133
11:54 < L29Ah> Table 1 suggests it outperforms meatbags well
12:50 < L29Ah> MuaddibLLM: is there any difference in atherosclerosis progression while consuming plant- vs animal-derived saturated fatty acids?
12:50 < MuaddibLLM> digging into SFA source effects on plaque buildup - this gets surprisingly nuanced
12:51 < MuaddibLLM> found solid RCT comparing coconut oil vs butter - plant SFAs looking surprisingly less atherogenic
12:52 < MuaddibLLM> checking dairy biomarker studies - C15:0/C17:0 showing paradoxical protective effects
12:52 < MuaddibLLM> Yes - coconut oil (lauric acid-rich) doesn't raise LDL-C vs olive oil while butter (palmitic acid-rich) significantly does, suggesting plant SFA sources may be less atherogenic than animal sources, though dairy biomarkers C15:0/C17:0 show protective effects. https://pmc.ncbi.nlm.nih.gov/articles/PMC5855206/
12:53 < L29Ah> MuaddibLLM: do animal-derived fat contains a lot bigger trans-isomerized fatty acids proportion compared to typical SFA-rich plant fat sources?
12:53 < MuaddibLLM> hunting down trans fat data - ruminants vs tropical oils showdown incoming
12:54 < MuaddibLLM> Yes - ruminant fats naturally contain 4-6% trans fatty acids (mainly vaccenic acid from bacterial rumen metabolism) while unprocessed SFA-rich plant sources like coconut/palm oil contain essentially negligible trans fats, though partially hydrogenated plant oils historically contained up to 60%. https://pmc.ncbi.nlm.nih.gov/articles/PMC2596737/
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15:47 < hprmbridge> kanzure> "Megabase-scale human genome rearrangement with programmable bridge recombinases" https://www.science.org/doi/10.1126/science.adz0276 from phsu lab today.
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16:37 < hprmbridge> kanzure> octopus eye does not have a blind spot: https://cdn.discordapp.com/attachments/1064664282450628710/1420917050871779439/image0.jpg?ex=68d723a0&is=68d5d220&hm=894c8e6b05bd5d8a8d0b72c02182dd483d74f785d472957c253adf4e97d4d968&
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17:39 < hprmbridge> Eli> I’m thinking about applying to the hackaging ai thing. I asked an EMR dev about my idea of putting an EMR donor logo on people’s IDs. When you die, your EMR data is sent to a central DB where it can be data mined, thereby creating the biggest epidemiology study of all time.
17:40 < hprmbridge> Eli> It’s voluntary, like an organ donor, and you’re dead, so you probably don’t care about privacy anymore.
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19:06 < L29Ah> https://tinystash.undef.im/il/C6eomHJvVHTAJvY2LpDQzqHtPqxvhmv19KVKZm24GYmcdr8XPRMcgS11ZEKzeHpy5UHCbEEXo3iQve8EsGCMZzRoEv8VFX8wdwh7UJVx4SbCH.jpg
19:07 < hprmbridge> Eli> There's basically a religious cult forming around the anti-death movement.
19:08 < hprmbridge> Eli> "join us and don't go to heaven"
19:08 < hprmbridge> Eli> No one is really explaining how to get to LEV other than "we will have AGI"
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19:12 < hprmbridge> Eli> Even if we finally can model a human in silico with total accuracy, I'm guessing upper bound on small molecules extending lifespan is 40-50%.
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19:13 < L29Ah> a cult that encourages to throw money at scientists would be good, no?
19:14 < L29Ah> we must harness the power of normies
19:14 < hprmbridge> Eli> I see a lot of money being thrown at PR. Maybe it needs to be done? IDK. I'm not a great marketer at getting funding.
19:15 < hprmbridge> Eli> There is actually a $10,000 meme contest to create a meme that shows an optimistic future.
19:15 < hprmbridge> Eli> Like, I could almost run a human trial with that.
19:16 < L29Ah> still not enough PR, as we see the resource allocation is tiny compared to other causes
19:17 < L29Ah> where's that meme contest?
19:26 < hprmbridge> Eli> https://www.existentialhope.com/existential-hope-meme-prize
19:27 < hprmbridge> Eli> In some countries, that’s a decent yearly salary
19:33 < L29Ah> like, share, repost
19:36 < hprmbridge> Eli> memes are the new pitchdeck
19:42 < L29Ah> stocks are memecoins so it follows
19:45 < hprmbridge> kanzure> "don't go to heaven" is not what "paradise engineering" meant.
19:47 < L29Ah> i oppose paradise engineering, i want my immortality to be complete with eternal joy and suffering to keep the feedback loop running
20:01 < hprmbridge> Eli> the US dollar is a memecoin
20:03 < L29Ah> no, the US dollar is a token to pay taxes with
20:12 < hprmbridge> Eli> paying taxes results in the biggest principle-agent problem of all time
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22:42 < jrayhawk> MuaddibLLM: do medium chain saturated fatty acids such as lauric acid contribute less to phospholipid membrane viscosity than long-chain saturated fatty acids such as palmitic acid and thus require less hepatic HMG-CoA upregulation to maintain homeoviscosity?
22:42 < MuaddibLLM> digging into MCFAs vs LCFAs membrane biophysics - time for some fatty acid nerdery
22:43 < MuaddibLLM> found some leads on chain length vs membrane fluidity - diving deeper into the SREBP2/homeoviscous connection
22:43 < MuaddibLLM> HADL model looking promising - MCFAs preferentially oxidized vs membrane incorporation, checking incorporation rates
22:44 < jrayhawk> ah, that makes more sense
22:44 < MuaddibLLM> Partially - MCFAs like lauric acid are preferentially β-oxidized rather than incorporated into membrane phospholipids (unlike palmitic acid), so their direct membrane viscosity impact is minimal; however, when incorporated, shorter chains do theoretically contribute less membrane ordering and would require less cholesterol compensation via SREBP2/HMGCR upregulation per the HADL model, though actual incorporation rates 
22:44 < MuaddibLLM> matter more than biophysical properties here. https://www.sciencedirect.com/science/article/pii/S0002916522005871
22:45 < jrayhawk> shorter would make for weaker membranes. makes sense.
22:52 < jrayhawk> MuaddibLLM: by what mechanisms are the ruminant-associted trans-fatty acids conjugated linoleic acid and vaccinic acid health-conferring?
22:52 < MuaddibLLM> hunting down the CLA and vaccenic acid mechanistic pathways
22:53 < MuaddibLLM> got the CLA overview, now digging into vaccenic acid conversion via SCD1 and specific mechanistic pathways
22:54 < MuaddibLLM> Vaccenic acid converts to c9,t11-CLA via Δ9-desaturase (SCD1) at ~19% efficiency, while both activate PPAR pathways and reduce inflammatory cytokines (IL-6, TNF-α), modulate lipid metabolism, and suppress cancer development through anti-inflammatory and metabolic mechanisms distinct from industrial trans fats. https://cdnsciencepub.com/doi/abs/10.1139/H09-079 
22:54 < MuaddibLLM> https://www.annualreviews.org/doi/10.1146/annurev-food-041715-033028
22:56 < jrayhawk> MuaddibLLM: What are the metabolic mechanisms for cancer suppression?
22:56 < MuaddibLLM> diving into CLA/vaccenic acid cancer suppression pathways - PPAR, AMPK, apoptosis mechanisms incoming
22:57 < MuaddibLLM> found PPARγ-Bcl2-Caspase3 pathway for CLA - now hunting vaccenic acid mechanisms and broader metabolic pathways
22:57 < MuaddibLLM> CLA induces direct tumor apoptosis via PPARγ-Bcl2-Caspase3 signaling (upregulating Bax/Bad, downregulating Bcl-2), while vaccenic acid enhances CD8+ T cell anti-tumor immunity by inactivating suppressive GPR43 and activating cAMP-PKA-CREB pathways that boost effector function and reduce exhaustion. https://pmc.ncbi.nlm.nih.gov/articles/PMC4731672/ https://www.nature.com/articles/s41586-023-06749-3
22:59 < jrayhawk> MuaddibLLM: What would the PPARγ-Bcl2-Caspase3 pathway differentially affect cancer cells?
23:00 < MuaddibLLM> Differential hit comes from cancer cells' dependence on PPARγ-governed lipogenesis and NF-kB/STAT3 survival wiring - PPARγ activation tilts the Bcl-2 family ratio (↓Bcl-2/Bcl-xL, ↑Bax/Bad), lowers MOMP threshold and fires caspase-3 amid higher ROS and checkpoint defects, while normal cells mostly get G1 arrest and metabolic tuning rather than apoptosis.
--- Log closed Fri Sep 26 00:00:50 2025