--- Log opened Sun Oct 05 00:00:59 2025
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06:34 < hprmbridge> kanzure> https://www.stanleyvonmedvey.com/pantheon
07:29 < hprmbridge> norkatron> fund the ability to be autonomous in space first
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09:09 < TMA> autonomous is more expensive than a colony (e.g. shielding is cheaper per unit of volume, because volume scales as x^3 while shielding as x^2)
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11:12 < kanzure> is there a good neuroanatomy benchmark i should be monitoring for LLM performance?
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14:21 < kanzure> "Working memory revived in older adults by synchronizing rhythmic brain circuits" https://pmc.ncbi.nlm.nih.gov/articles/PMC6486414/
14:22 < kanzure> "Delta-gamma coupling as a potential neurophysiological mechanism of fluid intelligence" https://www.sciencedirect.com/science/article/abs/pii/S0160289617301940
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15:00 < kanzure> claude decides to optimize human neurobiology https://diyhpl.us/~bryan/irc/chatgpt/2025-10-05-working-memory.txt from 7 + -2 working memory items to >20 working memory items.
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16:45 < hprmbridge> kanzure> "Closed-loop stimulation of temporal cortex rescues functional networks and improves memory" https://pmc.ncbi.nlm.nih.gov/articles/PMC5802791/
16:50 < hprmbridge> kanzure> "The importance of timing in segregated theta phase-coupling for cognitive performance" https://www.cell.com/current-biology/fulltext/S0960-9822(12)00574-X
16:54 < hprmbridge> kanzure> should be possible to make a generic 'cognitive pacemaker' out of a phase locked loop transcranial temporal interference stimulation + EEG. and it wouldn't require extensive genetic engineering to test some of that.
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17:04 < hprmbridge> kanzure> "interferential sinusoidal current stimulation" what now
18:40  * fenn plays around with a clothes iron, non-contact thermometer, and teflon-y coated paper backing tape for foil HVAC tape, with good results heat sealing PET foil bags @ 170C
18:43 < fenn> those DIAGNOX ketone strip bags, for vitamins that all seem to come in the useless flip-top bottles nowadays
19:23 < hprmbridge> kanzure> "Role of myelin plasticity in oscillations and synchrony of neuronal activity" https://pmc.ncbi.nlm.nih.gov/articles/PMC4037390/
19:31 < hprmbridge> kanzure> "Externally induced frontoparietal synchronization modulates network dynamics and enhances working memory performance" https://pmc.ncbi.nlm.nih.gov/articles/PMC5349849/
19:41 < L29Ah> TMA: evasion costs grow multiplicatively both with mass (more stuff to accelerate-decelerate) and with projected area (more large hyperspeed objects to avoid, larger course corrections to apply)
19:51 < hprmbridge> kanzure> "The subplate serves as a fetal/adolescent waiting compartment for cortical afferent fibers. Axon pathfinding for long-range cortico-cortical fibers proceeds through the intermediate zone/subplate which is a transient “waiting compartment” that hosts early synaptogenesis and guides corticocortical afferents. ... Apical radial glia (aRG) in the ventricular zone and basal/outer radial glia (bRG/oRG)
19:51 < hprmbridge> kanzure> in the expanded outer SVZ generate excitatory pyramids. The oRG pool is massively expanded in primates/humans, especially in frontal cortex, and is a key source of upper-layer (II/III) SATB2⁺ IT neurons that furnish association fibers. ... Developmental genetics specify projection identity: SATB2 promotes callosal/IT fate and represses CTIP2/FEZF2 (subcerebral) programs; perturbing this axis flips
19:51 < hprmbridge> kanzure> cortico-cortical neurons to subcortical targets in mice. .. Rostrolateral PFC (including BA10/RLPFC) progenitors sit under rostralizing morphogen gradients (e.g., FGF8/17; high PAX6), whereas IPL progenitors sit under relatively caudalizing gradients (e.g., EMX2/NR2F1/COUP-TFI). Early areal fate biases in these pools seed later differences in long-range connectivity. More late-born SATB2⁺ L2/3 IT
19:51 < hprmbridge> kanzure> neurons gives rise to more cortico-cortical axons available to form long association bundles like SLF II/III." trying to trace left RLPFC-IPL axon origin...
19:51 < hprmbridge> kanzure> "FGF8/17 (anterior organizer) and PAX6/EMX2/NR2F1 gradients set rostral–caudal cortical identity"
20:12 < hprmbridge> kanzure> cell type enhancers for targeting DLPFC https://www.biorxiv.org/content/10.1101/2024.12.01.626253v1
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21:58 < fenn> soldering iron and dymo label backing tape also works, although it needs more like 230C. with PP bags the soldering iron is too hot or has too much pressure or something and it infiltrates the HVAC backing tape and sticks and makes a fibrous mess
21:58 < fenn> my quecoo solder station only goes down to 200C unfortunately. at least i was able to turn off the incessant beeping
22:02 < fenn> plumber's teflon tape kinda melts into the LDPE and turns it opaque, but you can scrape it off mostly, not recommended
22:02 < fenn> er, PP not LDPE
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23:15 < fenn> "Open Printer will use the Creative Commons BY-NC-SA 4.0 license"
23:15 < fenn> sigh
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--- Log closed Mon Oct 06 00:00:00 2025