# Key Points from #hplusroadmap IRC Log (April 27, 2009)

• Discussion of portable MRI technology limitations, with debate about whether superconductors are necessary or if alternative approaches exist, noting the power requirements would be substantial without room-temperature superconductors.

• Exploration of multiphoton fluorescence microscopy with GFP for imaging up to 1mm into rat cortex (Theer et al. 2003) and optical atomic magnetometers for neuronal current detection with low-field magnetic resonance.

• Breakthrough in stem cell research mentioned where mouse cells were reprogrammed to form stem cells using only purified proteins and chemical additives, avoiding genetic material ("purely protein pluripotency").

• Detailed technical discussion about using picosecond/nanosecond laser pulses in water to generate cavitation bubbles, with analysis of resulting pressures (thousands of megapascals) and potential applications in waterjet cutting and cell lysis.

• Reference to artificial respiration technologies and hemoglobin mimetics, with discussion of a paper about devices that infuse oxygen directly into blood for dangerous environments like carbon monoxide-filled mines.

• Sharing of a detailed cell membrane diagram (http://heybryan.org/books/papers/Cell_membrane_detailed_diagram.svg) and discussion of MagA biobrick availability from a postdoc.

• Brief mention of GraphScholar (http://hublog.hubmed.org/archives/001002.html), a tool likely related to visualizing scientific literature connections.