# Key Points from #hplusroadmap IRC Discussions

• DIY microscopy techniques were explored, including the innovative use of water droplets as magnifiers, demonstrating the community's interest in developing accessible, low-cost scientific instrumentation alternatives.

• Participants discussed creating a graph grammar for chemical reactions that could automatically determine synthesis pathways for target compounds, representing efforts to automate and systematize organic chemistry processes.

• Microfluidic technologies were highlighted, including applications in gas chromatography and DNA synthesis, with specific references to phosphoramidite synthesis methods and in-situ DNA synthesis techniques.

• Nanomechanical biosensors were examined, particularly cantilever-based sensing technologies capable of detecting single base mismatches in DNA, showing interest in highly sensitive biological detection methods.

• A novel concept for creating black-and-white image sensors using arrays of biotinylated light-gated ion channels was proposed, suggesting innovative approaches to bio-electronic interfaces for visual sensing.

• The group discussed adaptive optics and liquid lens technologies, including electrowetting lenses and "origami optics," exploring their potential applications in creating adjustable-focus systems for miniaturized cameras.

• A biohacking technique involving bacteria attached to microchannels functioning as pumps in pressure-driven microfluidic systems was shared, demonstrating creative intersections between microbiology and engineering.