# Key Points from #hplusroadmap IRC Discussions

• Researchers discussed DNA origami technology for creating nanoscale DNA boxes with controllable lids, with potential applications in in vitro compartmentalization, directed evolution, and coupling genotypes to phenotypes for small molecules.

• Software tools for DNA origami design were shared, including SARSE for 2D and 3D structures, though participants noted practical limitations to DNA origami complexity related to oligonucleotide length.

• A significant breakthrough in graphene production was discussed, involving the creation of centimeter-sized squares of graphene, with speculation about potential applications of stacked graphene sheets.

• Chemical representation systems including SMILES, SMARTS, and SMIRKS were explored for molecular representation, canonicalization, and chemical reaction notation, alongside discussion of retrosynthetic analysis for working backward from target molecules.

• Participants debated the feasibility of creating graph grammars for organic chemistry, with differing opinions on the complexity and time requirements of such a project.

• Methods for encoding information in DNA were discussed, with suggestions to use base-four systems or consider Watson-Crick pairing when selecting nucleotides.

• The planning fallacy concept from Overcoming Bias blog was referenced in discussions about project planning and cognitive biases in estimating task completion times.