# Key Points from #hplusroadmap IRC Log

• A repository of scientific papers was established at http://adl.serveftp.org/heybryan/papers/ with significantly improved download speeds (9x faster), containing extensive collections of medical textbooks and reference materials.

• Discussions covered high-velocity water jet cutting technology development, with interest in creating water droplets moving at 300 m/sec for precision micromachining applications.

• Participants debated DIY biology safety approaches, advocating for practical machine-readable protocols that generate instruction manuals rather than relying on ethical oaths or creeds.

• Technical conversations explored DNA sequencing technologies, including microfluidic Sanger sequencing and AFM-based methods, with a proposal to crowdfund ($1,000) a DIY AFM DNA sequencer.

• The log contained references to artificial self-replicating systems, with shared images described as demonstrating "self-replication by condensation," potentially representing work in synthetic biology.

• Bacteriophage properties were discussed, including their remarkable internal pressure of 50 atmospheres, alongside the discovery that adding nine arginine residues to proteins enables silicon surface binding.

• Pandemic preparedness was addressed, particularly regarding H1N1 influenza and oseltamivir (Tamiflu), including chemical synthesis methods and concerns about viral resistance to neuraminidase inhibitors.