# Key Points from #hplusroadmap IRC Discussions

• Researchers shared resources on microrobotics and fabrication techniques from Berkeley's Microfabrication Interface, discussing implementation details of SKDB (structured knowledge database for manufacturing) including process taxonomy and feasibility scoring for different assembly methods.

• Technical discussions centered on evaluating manufacturing techniques (press-fitting, welding, gluing) based on geometric constraints and material properties, with participants sharing resources like Machinery's Handbook and formulas for interference fitting calculations.

• Neuroscience topics included "discourse comprehension" research, focusing on how the lateral prefrontal cortex and working memory help process conversational structure, with resources shared on MNI-to-Talairach coordinate conversion for brain mapping.

• DIY biology was a significant focus, with participants working on Python scripts to automate primer design using Biopython libraries and NCBI's Entrez database, while discussing PCR machines, RT-PCR data analysis, and protein quantification methods.

• One participant described developing a gene synthesizer with all reagents made from scratch to create technology "that can't be regulated," framing this approach as "technoanarchy" or "free-technology."

• Cognitive science discussions included research on how average people maintain "happy delusions" (unrealistic positive self-perceptions and unjustified optimism) as necessary mechanisms for daily functioning.

• Participants shared resources on advanced materials (transparent aluminum/electrides), semantic search facilitation, and cognitive enhancers including CX717 and Ampakines.