# Key Points from IRC Discussions

• Tim Schmidt planned to create CAD models of Gingery machines (DIY metalworking tools) and develop a wrench-buildable CNC machine, with potential kits if affordable materials could be sourced.

• Developers were actively working on SKDB (Standard Kit of Design Bits), an open-source hardware description system, including a LEGO package with CAD file loading capabilities and part mating interfaces.

• Kanzure was developing a YAML-based brain mapping project to represent human brain structures, including Brodmann areas and hypothalamic regions, with discussions about creating a coordinate system for brain regions.

• The team discussed important genes related to human brain evolution, including ASPM, CDK5RAP2, CENPJ, microcephalin, FOXP2, SHH, and HAR1, alongside conversations about cortical minicolumns and gyrification.

• Researchers shared tissue engineering techniques, particularly addressing vascularization challenges in tissue culture, noting that endothelial cells can form vascular networks when co-cultured with smooth muscle cells.

• The group criticized "Pearl Biotech" for claiming to develop open-source DIY biology hardware but failing to deliver promised schematics for over a year.

• Participants emphasized the importance of scientific data preservation, including backing up the entire NCBI database to ensure future access to genetic information.