# Key Points from #hplusroadmap IRC Discussions

• Researchers discussed integrating Python wrappers for OpenModelica and PyDaylight (a chemical analysis toolkit) for advanced computational modeling applications in biohacking and chemistry.

• Technical conversations explored DNA synthesis techniques using photolabile protecting groups, with specific interest in repurposing Blu-ray disk technology (405nm laser) for DNA microarray fabrication.

• The limitations of RepRap 3D printers were analyzed, highlighting their inability to fully self-replicate and their restriction to plastic parts with poor surface finish, prompting discussions about alternative manufacturing methods.

• Participants debated distributed manufacturing challenges, particularly the difficulties of small-scale steel production, with suggestions to explore biocatalysts for carbon nanotube production or growing materials convertible to composites.

• The SKDB (skill database) project was referenced as a platform for hardware specifications, supporting the aspirational concept of "downloading hardware" for distributed manufacturing systems.

• Laboratory automation tools were shared, including a link to Tecan Genesis robotics control software, demonstrating the community's focus on open-source scientific instrumentation.

• Cognitive enhancement was briefly discussed, with one participant mentioning plans to test the nootropic compound adrafinil (Olmifon).