# Key Technical and Conceptual Points from #hplusroadmap

• A team is developing DIY atomic force microscopy (AFM) and photolithography equipment with the ultimate goal of creating a complete clean room, with support from an AFM specialist professor who has grown his own scanning tips.

• The FreeFab project (freefab.org) is developing precision positioning systems for fabrication technology, with participants discussing DIY approaches including using PLA plastic (dissolvable in NaOH) for investment casting of metals.

• Open-source fabrication initiatives are gaining traction, with projects like the Open Source Fab Lab proposal and SKDB (a component-based design system that specifies connections between parts with CAD models) working to democratize advanced manufacturing capabilities.

• Participants discussed IBM's cat brain simulation presented at Supercomputing 2009, indicating interest in computational neuroscience advancements within the transhumanist community.

• The current market price for DNA synthesis was reported at $0.39 per base pair, suggesting ongoing monitoring of biotechnology costs relevant to biohacking projects.

• Discussions included spaced repetition learning software (SuperMemo) for memory optimization and conceptual explorations of "life optimization software" using permutation algorithms to maximize efficiency in everyday tasks.

• Resources for biohacking and transhumanism were shared, including DIYbio, iGEM, OpenWetWare, and Humanity+, framed in the context of "reverse engineering humans."