# Summary of #hplusroadmap IRC Discussion

• Participants discussed SkQ1 (plastoquinonyl-decyl-triphenylphosphonium), a mitochondria-targeted antioxidant developed by Russian scientist Vladimir Skulachev, debating its potential as a "magic bullet" for life extension and sharing biochemistry research papers on the compound.

• The group explored competing theories of aging, contrasting the view that aging is an adaptive genetic program that could be "hacked" versus the perspective that aging results from accumulated damage despite the body's attempts to maintain itself.

• Aubrey de Grey's SENS (Strategies for Engineered Negligible Senescence) was discussed, particularly the WILT component (Whole-body Interdiction of Lengthening of Telomeres) which would require periodic stem cell replacement therapy to prevent cellular deterioration.

• Kanzure referenced Tom Perls' 2010 study identifying genetic signatures of exceptional longevity in humans, specifically examining SNPs (single nucleotide polymorphisms) in centenarians that might contribute to extended lifespans.

• Information was shared about Noopept, a nootropic compound claimed to be 1000 times more potent than piracetam, with links to resources about cognitive enhancement compounds.

• Participants discussed the tension between intellectual property restrictions (NDAs) and open science, with kanzure expressing regret about signing agreements that limited sharing information that "could be derived from first principles."

• The conversation touched on DIY manufacturing technologies including CNC machines, RepRap, and CloudFab, reflecting interest in democratized production methods for transhumanist technologies.