# Key Points from #hplusroadmap IRC Discussion

• Participants debated ADHD as either a spectrum condition or distinct disorder, noting that ADHD-PI (formerly ADD) and ADHD-Hyperactive show different brain activity patterns in fMRI studies, while sharing personal experiences with Adderall's effects on focus, creativity, and emotional responses.

• Kanzure discussed enzyme engineering research focused on modifying DNA polymerase to switch between "creative" and "DNA-instructed" synthesis modes, with the goal of developing light-controlled or electrically-controlled DNA synthesis methods.

• Researchers noted that enzymatic DNA synthesis using polymerase is thousands of times more efficient than chemical oligonucleotide synthesis, with some polymerases having remarkably low error rates of 1-in-10,000.

• Technical discussions explored creating chimeric polymerases by potentially "stealing" binding pockets from existing ADP/GTP/CTP-binding enzymes with good selectivity, debating whether to use one giant enzyme or multiple carrier proteins.

• The group discussed Google's upcoming HUD (heads-up display) glasses, expressing excitement about mainstream adoption of wearable augmented reality while considering adaptations of "sixthsense" technology for HUD displays.

• A participant mentioned developing a brain input system to help a visually impaired friend, planning to create proprietary hardware with an open-source SDK over a 1-2 year development timeline.