# Key Points from Transhumanist IRC Discussions

• Participants discussed nootropic experiences, with reports that citicoline provided better motivation than aniracetam and helped overcome depression, while alpha-GPC was mentioned as an effective form of choline that enhances citicoline delivery.

• Technical discussions on genetic modification for intelligence included proposals to overexpress NR2B in rat hippocampus, with suggestions to either collaborate with experts like Joe Tsien or use computational models in NEURON simulators before attempting breeding experiments.

• A detailed circuit design for DIY transcranial direct current stimulation (tDCS) was shared, featuring constant current control (0-2mA), alongside discussion of advanced targeted tDCS using multiple electrodes, though some expressed skepticism about its effectiveness compared to ultrasound's 2mm resolution.

• Genetic engineering discussions included using the Allen Brain Atlas to identify region-specific gene expression for targeted transgene delivery, and simple protocols for sperm-mediated gene transfer (SMGT), though participants acknowledged the field remains unpredictable.

• Biohacking resources were shared, including a repository of scientific papers at http://diyhpl.us/~bryan/papers2/ covering longevity, stem cells, and neuroscience, along with references to DIY lab setups and GFP extraction projects.

• Educational tools were highlighted, including an interactive Python tutor and a JavaScript learning resource (http://learnjs.info/), alongside programming discussions about array and object methods in JavaScript.