# Key Points from Transhumanist and Biotech IRC Discussions

• Researchers discussed advanced approaches to DNA synthesis using microfluidic technology with computer-controlled microbubbles containing nucleotides, which could potentially enable high-throughput synthesis despite challenges with enzyme stability and reaction chamber design.

• Davidad described his ongoing C. elegans "upload" project using optogenetics (ChR2) and fluorescent imaging (GCaMP3) rather than contact electrodes, noting that C. elegans uses graded potentials requiring modeling the nervous system as a dynamical system with attractors rather than digital states.

• The conversation revealed tensions between open-source hardware initiatives and institutional recognition, with the newly formed Open Source Hardware Association (OSHWA) being rejected for 501c3 status for being "too promotional," while the IRS was placing special review on tax-exempt applications from organizations delivering open source technology.

• Participants discussed Halcyon Molecular's apparent pivot from DNA sequencing to synthesis after Oxford Nanopore's advances disrupted their business model, highlighting the rapid technological shifts in genomics and the challenges of commercializing cutting-edge biotechnology.

• A novel approach to producing spider silk (arachnofiber) using genetically modified duckweed plants was discussed, with estimates suggesting potential production of 1kg of silk per week using a small land area, though gene synthesis costs remained a challenge.

• The financial details of microfluidic technology company Fluidigm were analyzed, showing $82 million in assets and $28 million in product revenue (2011) with 67% product margins, despite accumulated net losses of $218 million, illustrating the economics of advanced biotech instrumentation.

• Davidad shared his career goal of "fixing research as an institution" and creating "the next Bell Labs," mentioning upcoming discussions with Peter Thiel about funding brain emulation research, reflecting the transhumanist community's interest in institutional innovation.