# Key Points from #hplusroadmap IRC Discussion

• A benchtop genome synthesis device is being developed by Kettner Griswold and Paul Sebexen, aiming to democratize the ability for labs to synthesize large genetic constructs in-house at low cost, potentially disrupting biotechnology and healthcare fields.

• Detailed discussion of DNA synthesis security protocols revealed extensive screening systems, including an HHS exclusion list containing 49,262 individuals and 2,792 businesses denied access to DNA synthesis services.

• The global spread of DIYbio community spaces was documented across multiple countries including Singapore, Brazil, Germany, Netherlands, Denmark, France, UK, Switzerland, India, and various North American cities.

• Transcripts from FBI-DIYbio conferences were shared, covering gene synthesis screening and community lab operations, though some materials were restricted at the request of the Defense Threat Reduction Agency (DTRA).

• Research on transcranial direct current stimulation (tDCS) highlighted significant challenges for DIY applications due to individual variability in cerebral cortex structure, as current flow follows paths of least electrical impedance and is affected by white matter fiber orientation.

• Discussion explored whether synthetic biology or molecular nanotechnology offers better pathways for developing artificial neurons and brain interfaces with greater precision than current microelectrode arrays or optogenetics approaches.