# Key Points from #hplusroadmap IRC Discussion

• Participants discussed specific genetic modifications for human enhancement, including CCR5-delta32 (HIV resistance), PCSK9 (reduced heart disease), MSTN double null (lean muscle), and LRP5 (stronger bones), with a comprehensive document on potential germline modifications shared.

• The World Anti-Doping Agency's (WADA) prohibition list was analyzed, noting its broad restrictions on "the transfer of nucleic acids or nucleic acid sequences" and genetically modified cells, effectively banning genetic enhancement in sports.

• Cambrian Genomics was highlighted as a company developing DNA laser printing technology, with notable advisors including George Church, Anselm Levskaya, and Reese Jones.

• A significant scientific visualization was shared: a live birth MRI video published in the American Journal of Obstetrics and Gynecology showing childbirth through real-time magnetic resonance imaging.

• Participants discussed gene therapy approaches for addiction treatment, specifically AAV-directed expression of anti-nicotine and anti-cocaine antibodies for smoking cessation and cocaine addiction.

• A UN report on the Economics of Ecosystems and Biodiversity was debated, particularly its estimate that insect pollination's global economic value was approximately $200 billion in 2005, which some participants considered unrealistically low.

• Technical developments in photolithography equipment were shared, including plans for an improved spin coater and a contact mask aligner for 2" wafers with vacuum chuck and adjustable microscopes.