# Key Ideas from #hplusroadmap IRC Discussions

• Participants explored genetic engineering approaches to cancer resistance, specifically discussing the potential benefits of duplicating the p53 gene and leveraging findings from the 1000 cancer genomes project to reduce cancer risk.

• The feasibility of genetically modifying bacteria to produce nootropics was debated, with experts clarifying that transplanting existing biosynthetic pathways is more practical than creating new ones, though still requiring significant expertise.

• Transcranial ultrasound was discussed as a neuromodulation technique, with references to clinical trials using phased arrays of transmitters and sharing of research papers on "Ultrasonic neuromodulation by brain stimulation."

• Users exchanged information about transcranial Direct Current Stimulation (tDCS), particularly regarding the spatial transition of effects between anode and cathode, with one participant planning to target both parietal lobes for cognitive enhancement.

• A technical conversation about game translation highlighted the advantages of working with disassembled code over binary editing, particularly for languages with grammatical gender and cases, using a Czech Pokémon Crystal translation project as an example.

• The channel itself was noted as a significant transhumanist community hub, with kanzure claiming it was the most active and long-lived transhumanist forum (60 people/day), while alternatives through Reddit were also considered.