# Key Points from #hplusroadmap IRC Discussion

- A scientific paper on retinal pigment epithelial physiology and pathophysiology was shared, highlighting ongoing interest in biological research relevant to transhumanist goals.

- Participants discussed a controversial blog post by a bioinformatician who quit the field, criticizing the lack of technical competence and poor software development practices in bioinformatics.

- There was consensus that scientific research would benefit significantly if researchers published their code alongside papers and participated in code reviews, addressing the quality issues in academic programming.

- Users identified specific problems with bioinformatics tools like the UCSC Genome Browser, including poor user experience and build processes that don't follow standard open source conventions.

- A need was identified for an open source NURBS (Non-Uniform Rational B-Spline) manipulation library to replace problematic options like OpenCASCADE, which would support open source hardware development.

- ImplicitCAD was tested and found functional but with significant performance limitations, as rendering time scales approximately as the cube of dimension, creating challenges for larger models.

- A proposal suggested replacing ImplicitCAD's underlying technology with NURBS manipulation to enable output to standard formats compatible with proprietary CAD tools, potentially attracting professional engineers to open-source alternatives.