# Key Ideas from #hplusroadmap Discussion

• Groundbreaking neuroscience research was shared, including studies on human glial progenitor cell engraftment enhancing synaptic plasticity in mice and whole-brain functional imaging at cellular resolution using light-sheet microscopy.

• Advanced brain imaging technology was highlighted, featuring a video demonstration of neuron-level functional activity visualization in zebrafish using the GCaMP5G calcium indicator.

• Ultrasound neuromodulation was argued to be superior to tDCS and TMS technologies due to its greater specificity (1mm² resolution) and deeper brain penetration capabilities.

• An implantable blood testing laboratory device that can be placed under the skin was discussed, representing significant advances in continuous health monitoring technology.

• Joe Kaufman's development of picomole-scale DNA/oligo synthesis technology was mentioned as potentially outperforming competitors in the field, though still pending patent approval.

• Participants discussed microfluidic approaches as a potential method to reduce reagent volumes in DNA synthesis, highlighting ongoing efforts to reduce costs in biotechnology.

• Several biotech organizations in the San Francisco area were mentioned as visit-worthy, including Transcriptic (a robotic cloud laboratory), Science Exchange, Lumnos Labs, 3scan, Thiel Foundation, and SENS Research Foundation.