# Key Insights from #hplusroadmap Discussions

• Researchers discussed CD47 protein's dual role in cancer treatment and angiogenesis promotion, alongside a separate analysis of a 115-year-old woman's genetic mutations showing oligoclonal hematopoiesis, both conversations highlighting cutting-edge biomedical research shared within the community.

• Blood-brain barrier permeability was explored in depth, with discussions of L-DOPA delivery mechanisms, natural sources like sprouted fava beans, and creatine dodecyl ester as a promising compound for crossing the BBB, demonstrating the group's focus on practical neurochemical interventions.

• Participants proposed using evolutionary algorithms to design molecules based on their performance in simulated chemical reactions, essentially performing "chemistry on a computer" - representing the computational approach to biochemical innovation.

• The economic structure of academic publishing was critically examined, with data showing Brazil spent $94 million on journal access in 2013 ($31 million to Elsevier alone), prompting discussions about open access alternatives and the challenges of reproducing scientific work from papers lacking sufficient detail.

• Sustainable architecture was discussed, particularly earthbag construction techniques developed by Nader Khalili that create earthquake-resistant and bullet-resistant dome structures, showing the group's interest in resilient living technologies.

• Technical discussions covered computational neuroscience research, including a paper simulating over 12,000 reconstructed neurons to study local field potentials, and debates about web technologies like fragment identifiers and AJAX crawling specifications that affect content indexing.

• Participants conceptualized an "ontological assimilator" system for extracting content from JavaScript-generated websites, while critiquing current web browsers for failing to be true "user agents" that prioritize users' interests over content providers.