# Key Technical and Conceptual Points from #hplusroadmap IRC

• Researchers discussed ultrasound-triggered microbubbles for targeted drug delivery, particularly noting how focused ultrasound with microbubbles can temporarily disrupt the blood-brain barrier to deliver large molecules to specific brain regions like the hippocampus.

• Technical discussions explored building phased array ultrasound systems for non-invasive neural stimulation, comparing spherical versus flat transducer arrays and the electronics needed to drive piezoelectric elements with precise timing.

• Participants examined spatial light modulators and phase modulation technology, including how LCD panels could be repurposed as phase modulators for applications ranging from maskless photolithography to potential gamma ray laser steering.

• A theoretical approach to reducing aging effects was proposed involving taking tissue samples from aged humans, modifying their methylation patterns to match younger DNA profiles, and reinjecting them into respective tissues.

• The group discussed the technical aspects of 3D displays using phased array optics, analyzing tradeoffs between spatial, temporal, angular, and intensity resolution in light field displays created with stacked LCD panels.

• Participants debated the theoretical limits of oxygen transport in blood, comparing hemoglobin's capacity to potential artificial alternatives like fluorocarbon-based microbubbles, with analysis of oxygen diffusion mechanics from blood vessels to neurons.

• The conversation touched on the neuroscience of conjoined twins Krista and Tatiana Hogan who share parts of their brain, noting the unusual neural connection that allows sensory experiences to be shared between them.