# Key Points from #hplusroadmap IRC Log

• A portable transcranial magnetic stimulator (SpringTMS) received FDA clearance for migraine treatment, featuring a single-pulse design in a compact form factor that makes TMS technology more accessible for clinical applications.

• Researchers discussed advances in miniaturized two-photon microscopy for imaging freely moving animals, highlighting progress in neural imaging technology that allows for observation of brain activity in natural behavioral contexts.

• Two advanced microscopy techniques were compared: two-photon excitation microscopy and light sheet fluorescence microscopy, with the latter offering visualization of approximately 100,000 neurons simultaneously in a single field of view.

• The IRC log contained detailed historical information about Oleg Losev, a pioneering Soviet scientist who invented early LEDs and transistor-like devices in the 1920s, developed a "light relay" based on Einstein's quantum theory, and created the "Crystodyne" radio before his death during the Siege of Leningrad.

• Technical discussion revealed that modern processor architecture has evolved beyond static clocking, with contemporary processors utilizing multiple clock domains that negotiate at edges, a design approach that has been standard since the post-80486 era.

• Participants expressed frustration about the continued paywalling of decades-old research papers, highlighting ongoing tensions between open science advocates and traditional academic publishing models.

• A brief exchange addressed misconceptions about open-source development, with kanzure noting that open-source approaches are not inherently "not-for-profit" in nature, challenging common assumptions about commercialization in open technology.