# Key Points from #hplusroadmap IRC Discussion

• Antivenom production was discussed as typically using polyclonal antibodies extracted as serum, with notable shortages and high costs (approximately $2,000 per vial of CroFab).

• The conversation explored DNA synthesis technologies, including POSAM/POGO inkjet DNA synthesizers referenced by George Church, and the technical limitations of using PDMS (polydimethylsiloxane) which swells with most DNA synthesis solvents.

• Participants discussed how specialized inkjet technology for DNA synthesis could be more affordable if manufacturers like HP would sell development kits, but they resist to protect their ink replacement business.

• A parametrically designed XY motion stage from MIT was shared as a potential resource for DIY lab equipment construction, demonstrating ongoing interest in open-source hardware for scientific applications.

• The group noted advancements in open-source CAD tools, with mentions of converting mcad.git to CadQuery and documentation of OpenCascade methods and gridbeam scaffolding systems on their wiki.

• "Kilobaser" was referenced as a DNA synthesis technology with a novel approach to corona treatment using microwave ovens, with potential significance if it can achieve 1 kilobase synthesis with low error rates.

• A matplotlib feature for XKCD-style sketch plotting was shared, highlighting tools for scientific data visualization within the community.