# Summary of #hplusroadmap IRC Discussion

• A paper on LEMS (Language for Expressing complex biological Models) was discussed, highlighting its importance for computational neuroscience modeling as the foundation for NeuroML 2, which enables hierarchical and concise representation of complex biological models.

• Resources for enzyme isolation were recommended, specifically Molecular Cloning by Sambrook and analytical chemistry textbooks focusing on separation techniques, providing practical guidance for biohackers and researchers.

• The conversation explored programming language design tradeoffs between creating new languages versus extending existing ones through macro systems, with specific comparison between Vala (which compiles to GObject/C) and macro-based approaches.

• A participant shared their implementation of algebraic data types for C using a custom macro system called "cmacro," sparking discussion about how this approach compares to similar features in modern languages like Rust.

• Methods for determining a company's client list were discussed, ranging from social engineering approaches (posing as prospective clients) to more direct methods like joining the company to gain insider access.

• Someone inquired about sourcing dermal microinjector matrix devices similar to those used in allergy testing, suggesting interest in DIY or experimental biomedical applications, though no definitive source was identified.