# Key Points from #hplusroadmap IRC Logs

• Researchers discussed a significant paper on "Bioengineered functional brain-like cortical tissue," representing advances in creating neural tissue structures that mimic actual brain functionality.

• The Neurokernel project was highlighted as an important Python framework for modeling the fruit fly brain on multiple NVIDIA GPUs, with participants noting that the Drosophila brain's modular structure simplifies simulation.

• Participants explored techniques for spatially localized RNA sequencing at different locations within in vitro neural tissue slices, discussing the implications for understanding neural tissue organization.

• A technical debate occurred regarding the current limitations of in vivo sequencing and single-cell genomic analysis, with researchers noting that complete genome sequencing from a single cell's DNA remains technically unfeasible.

• A cryptocurrency security discussion focused on SIGHASH_SINGLE signature type exploitation in Bitcoin and the need for deterministic signing, highlighting a potential weakness in OpenSSL's implementation.

• A Cryptome archive torrent was shared, providing access to a collection of leaked documents potentially relevant to privacy, security, and information freedom discussions.