# Key Points from #hplusroadmap IRC Discussion

• Participants compared research methodologies between biology and engineering, referencing "Can a biologist fix a radio?" which critiques how biologists study systems by removing components rather than understanding complete system architecture.

• Open-source biology tools were highlighted, including OpenTrons (a rapid prototyping platform) and Open qPCR (a $1300 DNA diagnostics device with open hardware and software), with detailed discussion of cost-effectiveness for on-farm pathogen testing.

• DIY alternatives to commercial lab equipment were explored, including a lightbulb-based PCR system buildable for approximately $50 plus $2 per test, compared to commercial kits costing over $250.

• 3D modeling and mesh generation tools were recommended, including SALOME, OpenCASCADE, and Python libraries for geometric operations and topology optimization in mechanical design.

• Academic publishing issues were discussed, including the Netherlands' VSNU terminating negotiations with Elsevier over open access, and alternative publishing models using web of trust systems for peer review.

• Progress in C. elegans simulation was shared, with links to locomotion models and a spreadsheet tracking the history of simulation efforts for this model organism.

• Emerging wearable technology was mentioned, including Nixie, a drone camera that can be worn around the wrist and deployed to take photos or videos, connecting to broader interests in tech-nomadism and wearable enhancements.