# Key Points from Transhumanist IRC Discussions

• Research on the DNA-binding protein Trnp1 was extensively discussed, highlighting how its regulation affects brain development through controlling both tangential expansion (when Trnp1 levels are high) and radial expansion with folding (when Trnp1 levels are low) in the cerebral cortex.

• Participants explored how cortical folding (gyrification) can be experimentally induced in typically smooth mouse brains through techniques like in utero electroporation and FGF2 protein injection at specific embryonic stages.

• The group debated whether cortical surface area or thickness is more predictive of cognitive ability, with research suggesting surface area correlates more strongly with general cognitive ability.

• Several genetic factors affecting brain development were identified, including rs133885 (MYO18B) as a potential marker for mathematical ability, KCTD8 associated with brain size in female adolescents, and various genes (Cux2, POU3F2/POU3F3, Nfib) influencing cortical thickness.

• A project on "exosenses" was discussed, involving tactile feedback systems using smartphones and actuated solenoids on a belt to create new sensory experiences, which later received DARPA funding.

• The conversation touched on ROCK inhibitors like fasudil and their potential cognitive enhancement effects, referencing research showing improved learning and working memory through peripheral delivery.

• Participants noted challenges in scientific communication, including the need for standardized computer-parseable formats for neuroscience data and difficulties with Wikipedia's policies when attempting to create articles about specialized research topics.