# Key Technical and Conceptual Points from #hplusroadmap Discussions

• Web-based 3D modeling tools were compared, with OpenJsCad highlighted for its good API and documentation, though it has recursion limitations, while other tools like TinkerCAD, Upverter, ShapeSmith, and VerbNURBS were mentioned with WebGL-based tools noted for superior rendering performance.

• Innovative approaches to peptide synthesis were discussed, including using ribosomes with synthetic tRNAs to potentially achieve 19x speedup over traditional chemical methods, with particular interest in "flexizyme" systems that could allow reusable, resin-immobilized ribozymes for tRNA aminoacylation.

• A significant debate occurred on biological versus diamondoid molecular nanotechnology approaches for transhumanist goals, with some arguing that biological systems are too limited for ambitious objectives like curing all diseases and mind uploading.

• Research on bacteriophage-mucus interactions was shared, revealing a novel non-host-derived immunity mechanism where bacteriophages adhere to mucus to provide antimicrobial defense on mucosal surfaces.

• A paper on soft 3D acoustic metamaterials with negative index was discussed for potential applications in ultrasonic brain stimulation at frequencies up to 500 KHz.

• Bluetooth Low Energy (BLE) technology was highlighted as an increasingly valuable tool for custom hardware development, particularly because it's supported on modern mobile platforms without requiring specialized authentication chips.

• PsyDB.net was shared as a specialized database for identifying and cataloging psychedelic trance samples and quotes in electronic music, addressing the challenge of tracking down obscure audio samples.