# Key Technical and Research Discussions from #hplusroadmap

• OpenWorm connectome implementation was discussed, with recommendations to import NeuroML files and engage with the OpenWorm community mailing list, which was described as "active and supportive" for those working on computational neuroscience models.

• CAD software options were compared, with Solidworks recommended for commercial use despite its educational package limitations ($150 with only one-year activation), while alternatives included reverse engineering STL files into OpenSCAD models for open-source workflows.

• Advanced biomaterials research was highlighted, particularly silk-based materials that achieve impressive mechanical properties through natural physical crosslinks (beta sheets) without requiring exogenous crosslinking reactions, while offering functionalization with cytokines and cell binding domains.

• A notable bioprinting advancement was shared regarding a "bionic ear" created through 3D printing that combined alginate hydrogel matrix pre-seeded with viable chondrocytes and silver nanoparticle-infused silicone to integrate biological, electronic, and structural components in a single process.

• Microbiome sequencing services were discussed, with uBiome offering 16S sequencing for $89 per sample without preprocessing requirements, capable of processing any mixed bacterial sample beyond just human microbiome applications.

• Gene synthesis options were evaluated, with IDT's gBlocks identified as one of the best options for small gene synthesis ($89 for 500bp to $329 for 2000bp), though participants expressed disappointment about size limitations.