# Key Ideas from #hplusroadmap IRC Discussion (January 22, 2015)

• MIT researchers developed "expansion microscopy," a technique that allows examination of fine cellular structures using common microscopes by expanding tissue samples 4.5 times their normal size with polymer building blocks similar to those in diapers.

• Participants debated the Fermi Paradox, with some arguing that the absence of visible large-scale galactic engineering provides strong evidence against advanced extraterrestrial civilizations, while others suggested such engineering might be misinterpreted as natural phenomena.

• The channel discussed r/K selection theory in relation to extraterrestrial intelligence, debating whether advanced civilizations would follow r-strategy (many short-lived offspring) or K-strategy (fewer, longer-lived offspring) when spreading through the galaxy.

• An "intelligent keyboard" (IKB) was discussed that can recognize users by their typing patterns for security purposes while also harvesting electricity from typing motions.

• DIY drug design approaches were explored, with participants discussing potential targets for molecular design including antimicrobials, neuroreceptor ligands, and HIV receptors.

• Cold boot attacks on computer memory were analyzed, noting that at -50°C fewer than 1% of DRAM bits decayed after 10 minutes without power, while at liquid nitrogen temperatures (-196°C) only 0.17% decayed after 60 minutes.

• A low-cost DIY laser engraver/cutter was discussed for potential applications in photoresist exposure and PCB fabrication.