# Key Points from #hplusroadmap IRC Discussion

• Library Genesis released a massive 28 TB public torrent containing 38 million scientific articles organized by DOI and packaged in 1000-article ZIP archives, representing a significant open science initiative.

• Participants critiqued a controversial CRISPR human embryo editing paper, noting its methodological flaws using double-fertilized eggs likely contributed to poor results that may have incorrectly suggested limitations in CRISPR's efficacy.

• A water/heptane interface method for continuous graphene synthesis was discussed, though the 250W ultrasonic transducer requirement presents a cost barrier to implementation.

• Research on small passerine birds revealed their inability to use basic deduction, with examples of irrational behaviors like incubating dead chicks or bringing food to empty nests, highlighting limitations in avian cognition.

• The pond snail Lymnaea stagnalis was identified as an excellent model organism for memory studies due to its well-described neural system where a single neuron controls long-term memory expression.

• DNA methylation was discussed as a key mechanism in memory enhancement, with the methyltransferase inhibitor 5-aza-2′-deoxycytidine shown to block enhanced memory persistence in snails.

• Kanzure specifically sought research on methyltransferase's role in memory reconsolidation rather than amnesia, with relevant papers on DNA methyltransferase activity in neural plasticity being shared.

• A technical discussion about sensors with long convergence times suggested that while single sensors might be impractical for scanning, deploying multiple sensors simultaneously could enable effective scanning capabilities.