# Key Technical and Conceptual Points from #hplusroadmap

• A significant advancement in cryo-electron microscopy (cryo-EM) achieved 0.22 nanometer resolution of the β-galactosidase protein, enabling visualization of water molecules binding to the protein, though not quite reaching atomic-level resolution.

• Participants debated whether neural connectivity patterns alone are sufficient for mind uploading, with some arguing that critical information exists beyond the connectome, including mechanisms like Hebbian learning, synaptic density changes, and axon guidance.

• An ocean virus mapping study revealed that out of 5,476 viral populations identified, only 39 were previously known to science, highlighting vast undiscovered biodiversity in marine viruses.

• The Logjam TLS vulnerability was discussed alongside security concerns about non-physical true random number generators that use SSDs as entropy sources, which lack the physical phenomena (like spin variations in traditional hard disks) needed for true randomness.

• ConvNetJS was highlighted as a JavaScript library enabling browser-based deep learning model training without requiring software installation, compilers, or GPUs.

• Researchers discussed conflicting findings about GDF11, a protein related to aging, with disagreement about whether it increases or decreases with age and its effects on skeletal muscle regeneration.

• A technical discussion explored using phased arrays of phase-locked lasers to focus beams over extremely long distances, calculating that a 50-kilometer baseline would be needed to create a 1mm spot at lunar distance.