# Key Points from #hplusroadmap IRC Discussion

• Researchers discussed neural interface approaches, contrasting electrical connections with optical networks (optogenetics), noting that optogenetics might be less damaging to brain tissue but is currently limited to a few wavelengths.

• Genetic modification for cognitive enhancement focused on the DRD2 gene and rs1800497 polymorphism (Taq1A), which affects dopamine synthesis and working memory, though participants raised concerns about associated risks including personality disorders.

• Participants shared research on "senolytics" (including quercetin and dasatinib) from Scripps and Mayo Clinic published in Aging Cell, describing drugs that selectively eliminate senescent cells that accumulate with aging, potentially increasing healthspan.

• A PLOS Computational Biology paper was discussed regarding inferring regulatory networks from experimental morphological phenotypes, specifically about reverse-engineering planarian regeneration.

• The conversation touched on genetic complexity, referencing a Nature Genetics paper showing that 697 genes together account for only one-fifth of the heritability of adult height, highlighting the challenges in understanding polygenic traits.

• Participants debated the practical utility of graph visualization tools like Graphviz, with most agreeing they rarely extracted useful information from such visualizations compared to simple data lists.

• Temple Grandin's approach to autism research was mentioned, specifically her recommendation to group research subjects by main symptoms and self-reports rather than solely by diagnosis.