# Summary of #hplusroadmap IRC Log (July 4, 2015)

* Research on memory persistence was shared, highlighting that the prion-like protein CPEB3 plays a crucial role in hippocampal-based memory through protein synthesis and aggregation, with genetic ablation of CPEB3 impairing both hippocampal long-term potentiation and spatial memory.

* Several related papers were discussed about CPEB3, including one showing that SUMOylation regulates the prion-like aggregation of CPEB3, and another revealing that CPEB3 has a tripartite organization that interacts with the actin cytoskeleton.

* Research was shared indicating that Neuralized1 overexpression in mice (which influences CPEB3) shows memory improvements and increases the number of synapses, suggesting potential pathways for memory enhancement.

* A discussion about DNA methylation in neuron function was referenced, specifically related to memory formation rather than memory persistence, with a link to a paper on the topic (http://diyhpl.us/~bryan/papers2/neuro/DNA%20methylation%20in%20memory%20formation%20-%20emerging%20insights%20-%202015.pdf).

* A user mentioned that Nikola Danaylov (host of Singularity 1-on-1 podcast) deleted a comment questioning whether Michio Kaku had appropriated the Kardashev scale without proper attribution.

* The Los Angeles biohackers group was mentioned with a link to their 3D printing advertisement.