# Summary of IRC Log from July 5, 2015

* David Pearce was discussed for his unusual practice of owning thousands of domain names (approximately 10,000) with minimal content on each, with kanzure sharing a partial list of 3,700 domains and noting that Pearce is "well known for having purchased 10,000 domain names and keeping only a single page of content on each one."

* A discussion on molecular machines and nanoscale structures took place, with kanzure sharing a link to a differential gear mechanism and noting that current abilities to make nanoscale structures are limited, suggesting the value of "having a general library of structural nanosystems."

* Two scientific papers were shared: "Trapping a transition state in a computationally designed protein bottle" from Baker Lab and "Prediction of nucleic acid binding probability in proteins: a neighboring residue network based score" from Oxford Journals.

* CaptHindsight initiated a discussion about quality control in DNA synthesis, questioning whether error correction should be built into synthesizers or performed at the end of synthesis, and comparing different approaches including inkjet (96 samples per tray) versus DLP technology (potentially 2.3 million per tray).

* Agilent's inkjet technology for DNA microarrays was mentioned as achieving ">99% efficiency," though participants questioned what this efficiency metric actually measured and noted the difference between oligo probe hybridization and sequences designed to be combined into larger sequences.