# Key Ideas from Transhumanist and Biohacking Discussions

• Detailed discussions on plant grafting revealed biological compatibility constraints, with evidence that while grafting works within related species (like various apple varieties), it cannot transfer properties between unrelated species, as demonstrated by cannabis-to-hops grafting research showing THC production remains limited to cannabis flowers.

• A significant conversation explored the commercial and technical challenges of developing biosimilar antibodies for cancer treatment, including protein purification methods (Protein A columns, ion-exchange, size-exclusion chromatography) and the economic barriers to market entry ($150M for FDA approval versus $250K for initial cell line development).

• Alternative market strategies for biosimilar development were analyzed, including manufacturing in countries with less stringent regulations or targeting developing nations, highlighting the tension between innovation and regulatory compliance in medical biotechnology.

• Participants questioned why monocyte banking isn't pursued as an anti-aging strategy, noting resistance from blood donation organizations and suggesting interest in personal cell preservation technologies.

• Research on biological aging mechanisms was shared, particularly a paper on "Repression of the heat shock response is a programmed event at the onset of reproduction," indicating ongoing interest in the molecular basis of aging.

• The benefits of fasting were briefly discussed as a longevity strategy, specifically mentioning immune system reset and improved insulin sensitivity as potential mechanisms for life extension.

• A link to liver regeneration research (https://srconstantin.wordpress.com/2015/07/19/we-could-regrow-livers/) was shared, demonstrating interest in organ regeneration technologies.