# Key Ideas from #hplusroadmap IRC Discussions

• Participants explored advanced DNA synthesis technologies, particularly using inkjet printheads to perform separate chemical reactions in millions of spots simultaneously as an alternative to traditional column-based synthesizers, while noting the limitations of phosphoramidite chemistry (only effective for 20-100 base pairs).

• Microfluidic approaches including EWOD (electrowetting on dielectric) and SCOEW technologies were discussed as methods for moving droplets on surfaces without valves, with debate about technical specifications and the possibility of using CRTs and electron guns as alternatives to LCD screens for microscale chemical reaction control.

• The group contrasted "rationality bootcamps" (where people live together solving math problems) with potential biohacking bootcamps that would teach practical skills like reverse engineering and cell transformation techniques.

• AI safety concerns were debated, with some arguing that Yudkowsky's worries apply primarily to reinforcement learning systems with undirected search, while others maintained these concerns apply to any goal-directed AI regardless of architecture.

• Participants discussed whether language understanding tests (like cloze deletion) could effectively measure progress toward general intelligence, alongside mentions of custom proteins that could create precise molecular nanostructures despite currently high design costs.

• The conversation included mechanical engineering resources, specifically a YouTube channel (thang010146) featuring various mechanical linkages and mechanisms for "keeping direction unchanged during rotation" and "converting two-way linear motion into one-way rotation."