# Summary of IRC Log from #hplusroadmap (August 24, 2015)

• A significant scientific advancement was shared regarding the structure of a yeast spliceosome at 3.6 angstrom resolution determined by single particle cryo-electron microscopy (cryo-EM), which helps understand the molecular mechanism of pre-messenger RNA splicing.

• A discussion about aging research companies noted that in 80+ years of modern aging research, fewer than 12 companies had been formed with only 3 being monetized (IKARIA, Fold Rx & Sirtris), with Sirtris being described as a "scientific-business failure" despite its $720 million acquisition by GSK.

• A resource for academic torrents was shared (academictorrents.com), providing a platform for sharing large scientific datasets and papers.

• A technique for de-encapsulating integrated circuits using a laser cutter was discussed, with some concerns about how this might affect fuses in the chips.

• An interesting neuroscience paradox was discussed regarding hydrocephaly cases where people with only 5% of normal brain matter can function normally, raising questions about why humans evolved large, energy-intensive brains if so much tissue isn't necessary.

• The article "Effect of Simulated Microgravity on Human Brain Gray Matter and White Matter – Evidence from MRI" was shared, examining how microgravity conditions affect brain structure.

• A brief discussion about PCR equipment for DIY biology took place, with mentions of OpenPCR and OpenRTPCR options, and considerations about building a capillary gel system with microcapillary tubes for checking DNA fragment length.