# Key Points from #hplusroadmap IRC Discussion

• Researchers discussed a Nature article examining genome-wide analysis of extremely high intelligence (IQ >170), which found that rare functional alleles appear more frequently detrimental than beneficial to intelligence, with protein-altering variation yielding a heritability estimate of 17.4%.

• The conversation highlighted potential gaps in intelligence research, suggesting that working memory set size and spatial ability might have stronger genetic correlations than general IQ and better predict occupational and creative accomplishments.

• Several binary visualization tools for reverse engineering were shared, including binglide on GitHub and binvis.io, along with a YouTube demonstration of their capabilities.

• A Stanford research study was referenced claiming that cooling gloves for reducing core body temperature could produce muscle hypertrophy effects "comparable to steroids."

• Participants discussed a paper on phase transitions in network structures as a possible explanation for major evolutionary transitions in biological complexity.

• Practical biohacking discussions included sourcing fetal bovine serum (FBS) for cell culture work, with users seeking cost-effective suppliers at around $250/500mL.

• The gene PLXNB2 (Plexin-B2), which encodes a protein involved in axon guidance and cell migration, was mentioned in the context of neurological bases for cognitive abilities.