# Key Points from #hplusroadmap IRC Logs

• Scientific developments in aging research were shared, including a paper on "Concise total synthesis of glucosepane" and discussion of a drug called glyburide/cirara that reportedly reduces mortality from major stroke by 60%.

• A significant debate occurred about LessWrong and HPMOR (Harry Potter and the Methods of Rationality), with critics arguing they distract from practical transhumanist work while defenders emphasized fiction's role in inspiring interest in rationality and transhumanism.

• Participants discussed the BioViva case where CEO Liz Parrish self-administered follistatin and telomerase gene therapies, with technical critiques about the lack of reporter genes for verification and concerns about cancer risks from telomerase upregulation.

• The community debated DIY clinical trials and biohacking approaches, including the feasibility of crowdfunding trials, sourcing compounds like nervonic acid, and navigating the regulatory barriers that make formal clinical trials prohibitively expensive.

• Conversation touched on anti-aging mechanisms, with discussions about DNA repair, oxidative damage, and the complexity of aging genetics, noting that effective interventions would likely involve multiple genes rather than a single approach.

• Kanzure shared resources including an updated list of biology hackerspaces and visual simulations such as a WebGL mechanical clock, demonstrating the community's interest in practical tools and collaborative spaces.

• The challenges of finding collaborators for transhumanist projects were discussed, with participants suggesting that money, time, and community-building are key factors in getting more people involved in practical work.