# Summary of IRC Log Discussion (October 31, 2015)

* Research on Chondroitinase ABC (ChABC) was extensively discussed, highlighting its ability to reactivate neural plasticity by degrading chondroitin sulfate proteoglycans (CSPGs), with potential applications for treating memory loss in neurodegenerative disorders, promoting axonal growth in Parkinson's disease models, and enabling spinal cord regeneration after injury.

* Several scientific papers were shared about ChABC, including studies showing restoration of memory in mice with tau pathology, enhanced axonal growth along the nigrostriatal pathway, and complete functional recovery after spinal cord transection when delivered at high doses.

* Researchers have improved ChABC enzyme activity through site-directed mutagenesis, with specific mutations (Asn795Ala and Trp818Ala) showing 1.4-1.8 times higher activity than the wild type enzyme, potentially enhancing therapeutic applications.

* A brief discussion of Aboriginal Linux was mentioned, which aims to replace cross-compiling with native compiling under an emulator (QEMU), offering a potential solution for development across different computing architectures.

* There was a short exchange about transcranial direct current stimulation (tDCS), with criticism that while it works in clinical trials, its current implementations lack the desired spatial resolution (1 mm³) for precise targeting of specific brain regions.