# Key Points from #hplusroadmap IRC Discussion

• Cryonics legal challenges were discussed, particularly the "Rule against perpetuities" affecting cryonics trusts, with Alcor having researched jurisdictions where effectively perpetual trusts can be established.

• The "First Quantified Brain" project (MyConnectome) was highlighted, featuring a single subject who underwent MRI scanning twice weekly for 18 months, providing unprecedented data on brain connectivity variations.

• OpenAI's launch was announced with a billion-dollar fund dedicated to artificial intelligence research, representing a major investment in open AI development.

• A technical discussion covered semiconductor manufacturing challenges, including high-k metal gate transistors and quantum tunneling issues when gate oxide layers become extremely thin.

• Kanzure proposed an innovative research concept for developing cryopreservation capabilities through artificial selection of mice with enhanced freeze/thaw survival traits.

• The potential of brain-infecting microbes as nootropics was explored, with suggestions for engineering brain-compatible microbes to express neural growth factors that could enhance cognition.

• Participants debated far-future computing architectures like "Jupiter brains" (planet-sized computational structures) and the feasibility of self-replicating robots capable of planetary disassembly for advanced computation.

• Space-based replicators were discussed as a pathway to large-scale space engineering, with observations about replication cycle timeframes and environmental considerations.